Evidence map›Paper›PMID 39125491›Full record

ArticleDiagnostics (Basel, Switzerland)2024

Compact Linear Flow Phantom Model for Retinal Blood-Flow Evaluation.

Achyut J Raghavendra, Abdelrahman M Elhusseiny, Anant Agrawal, Zhuolin Liu, Daniel X Hammer, Osamah J Saeedi

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Diagnostics (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Achyut J RaghavendraDepartment of Ophthalmology and Visual Sciences, University of Maryland School of Medicine, Baltimore, MD 21201, USA.ORCID 0000-0002-2463-4580
Abdelrahman M ElhusseinyDepartment of Ophthalmology, Harvey and Bernice Jones Eye Institute, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA.
Anant AgrawalCenter for Devices and Radiological Health (CDRH), U.S. Food and Drug Administration (FDA), Silver Spring, MD 20993, USA.ORCID 0000-0001-8573-0042
Zhuolin LiuCenter for Devices and Radiological Health (CDRH), U.S. Food and Drug Administration (FDA), Silver Spring, MD 20993, USA.ORCID 0000-0001-8019-2054
Daniel X HammerCenter for Devices and Radiological Health (CDRH), U.S. Food and Drug Administration (FDA), Silver Spring, MD 20993, USA.ORCID 0000-0003-0532-1914
Osamah J SaeediDepartment of Ophthalmology and Visual Sciences, University of Maryland School of Medicine, Baltimore, MD 21201, USA.ORCID 0000-0002-3082-4604

Funding

Direct Measures of Retinal Blood Flow and Autoregulation as Robust Biomarkers for Early GlaucomaR01EY031731 · NEI · UNIVERSITY OF MARYLAND BALTIMORE · PI SAEEDI, OSAMAH JAWAID · 2021 to 2025
$1.6M
National Eye In-318 stitute/National Institutes of Health R01EY031731NEI NIH HHS R01 EY031731United States Food and Drug Administration M-CERSI
6 · The paper itself

Abstract

Impaired retinal blood flow is associated with ocular diseases such as glaucoma, macular degeneration, and diabetic retinopathy. Among several ocular imaging techniques developed to measure retinal blood flow both invasively and non-invasively, adaptive optics (AO)-enabled scanning laser ophthalmoscopy (AO-SLO) resolves individual red blood cells and provides a high resolution with which to measure flow across retinal microvasculature. However, cross-validation of flow measures remains a challenge owing to instrument and patient-specific variability in each imaging technique. Hence, there is a critical need for a well-controlled clinical flow phantom for standardization and to establish blood-flow measures as clinical biomarkers for early diagnosis. Here, we present the design and validation of a simple, compact, portable, linear flow phantom based on a direct current motor and a conveyor-belt system that provides linear velocity tuning within the retinal microvasculature range (0.5-7 mm/s). The model was evaluated using a sensitive AO-SLO line-scan technique, which showed a <6% standard deviation from the true velocity. Further, a clinical SLO instrument showed a linear correlation with the phantom's true velocity (

Indexed as

adaptive opticsdiabetic retinopathyglaucomaphantomretinal blood flowscanning laser ophthalmoscopy

Identifiers

PMID39125491
PMCPMC11311845

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.