Evidence map›Paper›PMID 39125388›Full record

ArticleNutrients2024

Adherence to a Cholesterol-Lowering Diet and the Risk of Pancreatic Cancer: A Case-Control Study.

Matteo Di Maso, Livia S A Augustin, David J A Jenkins, Anna Crispo, Federica Toffolutti, Eva Negri, Carlo La Vecchia, Monica Ferraroni, Jerry Polesel

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nutrients, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Matteo Di MasoDepartment of Clinical Sciences and Community Health, Department of Excellence 2023-2027, Branch of Medical Statistics, Biometry and Epidemiology "G.A. Maccacaro", Università degli Studi di Milano, via Celoria 22, 20133 Milan, Italy.ORCID 0000-0002-6481-990X
Livia S A AugustinEpidemiology and Biostatistics Unit, Istituto Nazionale Tumori-IRCCS-"Fondazione G. Pascale", via M. Semmola 1, 80131 Naples, Italy.ORCID 0000-0002-6673-8281
David J A JenkinsDepartments of Nutritional Science and Medicine, Temerty Faculty of Medicine, University of Toronto, Toronto, ON M5S 1A8, Canada.ORCID 0000-0003-1192-9571
Anna CrispoEpidemiology and Biostatistics Unit, Istituto Nazionale Tumori-IRCCS-"Fondazione G. Pascale", via M. Semmola 1, 80131 Naples, Italy.
Federica ToffoluttiUnit of Cancer Epidemiology, Centro di Riferimento Oncologico di Aviano (CRO), IRCCS, via F. Gallini 2, 33081 Aviano, Italy.ORCID 0000-0002-2907-0745
Eva NegriDepartment of Medical and Surgical Sciences, Alma Mater Studiorum, Università di Bologna, via P. Palagi 9, 40138 Bologna, Italy.
Carlo La VecchiaDepartment of Clinical Sciences and Community Health, Department of Excellence 2023-2027, Branch of Medical Statistics, Biometry and Epidemiology "G.A. Maccacaro", Università degli Studi di Milano, via Celoria 22, 20133 Milan, Italy.ORCID 0000-0003-1441-897X
Monica FerraroniDepartment of Clinical Sciences and Community Health, Department of Excellence 2023-2027, Branch of Medical Statistics, Biometry and Epidemiology "G.A. Maccacaro", Università degli Studi di Milano, via Celoria 22, 20133 Milan, Italy.ORCID 0000-0002-4542-4996
Jerry PoleselUnit of Cancer Epidemiology, Centro di Riferimento Oncologico di Aviano (CRO), IRCCS, via F. Gallini 2, 33081 Aviano, Italy.ORCID 0000-0001-9381-1520

Funding

Italian Ministry of Health (Ricerca Corrente) no grant number provided
6 · The paper itself

Abstract

backgroundPancreatic cancer risk has been associated with increased serum cholesterol level, which is in turn partially influenced by diet. This study aimed at evaluating the association between pancreatic cancer risk and the adherence to a plant-based cholesterol-lowering diet.

methodsData were derived from an Italian case-control study including 258 pancreatic cancer patients and 551 controls. The cholesterol-lowering diet score was based on seven components: high intakes of (i) non-cellulosic polysaccharides (a proxy of viscous fibers), (ii) monounsaturated fatty acids, (iii) legumes, and (iv) seeds/corn oils (a proxy of phytosterols); and low intakes of (v) saturated fatty acids, (vi) dietary cholesterol, and (vii) food with a high glycemic index. The score was calculated adding one point for each fulfilled component, thus ranging from zero (no adherence) to seven (complete adherence). The odds ratios (ORs) and 95% confidence intervals (CIs) were estimated through the logistic regression model.

resultsScores 5-7 were associated with reduced cancer risk (OR = 0.30; 95% CI: 0.18-0.52) compared to scores 0-2.

conclusionsAdherence to a plant-based cholesterol-lowering diet was associated with a reduced risk of pancreatic cancer.

Indexed as

Pancreatic NeoplasmsAgedCase-Control StudiesCholesterolCholesterol, DietaryFemaleHumansItalyMaleMiddle AgedOdds RatioPatient ComplianceRisk FactorsCholesterolCholesterol, Dietarycholesterolpancreatic cancerplant-based diet

Identifiers

PMID39125388
PMCPMC11314520

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.