Evidence map›Paper›PMID 39125328›Full record

ArticleNutrients2024

Markers of Intestinal Permeability and Inflammation in Enterally Fed Children with Cerebral Palsy.

Dorota Mickiewicz-Góra, Katarzyna Sznurkowska, Karolina Skonieczna-Żydecka, Arleta Drozd, Anna Borkowska, Maciej Zagierski, Joanna Troch, Agnieszka Szlagatys-Sidorkiewicz

Abstract read
In one paragraph

Article in Nutrients, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Dorota Mickiewicz-GóraDepartment of Paediatrics, Gastroenterology, Allergology & Paediatric Nutrition, Medical University of Gdansk, 80-803 Gdansk, Poland.ORCID 0000-0001-9607-9320
Katarzyna SznurkowskaDepartment of Paediatrics, Gastroenterology, Allergology & Paediatric Nutrition, Medical University of Gdansk, 80-803 Gdansk, Poland.
Karolina Skonieczna-ŻydeckaDepartment of Biochemical Science, Pomeranian Medical University in Szczecin, 70-204 Szczecin, Poland.ORCID 0000-0002-3430-9079
Arleta DrozdDepartment of Human Nutrition and Metabolomics, Pomeranian Medical University in Szczecin, 70-204 Szczecin, Poland.ORCID 0000-0002-5816-2040
Anna BorkowskaDepartment of Paediatrics, Gastroenterology, Allergology & Paediatric Nutrition, Medical University of Gdansk, 80-803 Gdansk, Poland.
Maciej ZagierskiDepartment of Paediatrics, Gastroenterology, Allergology & Paediatric Nutrition, Medical University of Gdansk, 80-803 Gdansk, Poland.ORCID 0000-0002-4572-6257
Joanna TrochDepartment of Paediatrics, Gastroenterology, Allergology & Paediatric Nutrition, Medical University of Gdansk, 80-803 Gdansk, Poland.
Agnieszka Szlagatys-SidorkiewiczDepartment of Paediatrics, Gastroenterology, Allergology & Paediatric Nutrition, Medical University of Gdansk, 80-803 Gdansk, Poland.ORCID 0000-0002-5992-4414

Funding

Gdańsk Medical University NKBBN/324/2017
6 · The paper itself

Abstract

Cerebral palsy (CP) results in non-progressive damage to the central nervous system, leading to functional disorders of the gastrointestinal tract and requiring enteral nutrition via gastrostomy in some patients. The aim of the study was to assess the impact of enteral nutrition on intestinal inflammation expressed by stool calprotectin and intestinal permeability determined by fecal zonulin and IFABP, and to determine whether CP affects these parameters. The study group consisted of 30 children with CP, fed enterally (Cerebral Palsy Enteral Nutrition-CPEN), and two reference groups: 24 children with CP, fed orally with a standard diet (CPC-Cerebral Palsy Controls) and 24 healthy children (HC-healthy controls). The differences between these groups and between the combined CP groups (CPG and CPEN + CPC) and HC were analyzed. Fecal zonulin, calprotectin, and intestinal fatty acid-binding protein 2 (IFABP2) levels were determined by ELISA. The concentrations of fecal calprotectin and zonulin were significantly higher in the CPEN group than in the CPC group (

Indexed as

BiomarkersCerebral PalsyCholera ToxinEnteral NutritionFecesHaptoglobinsIntestinal Barrier FunctionLeukocyte L1 Antigen ComplexProtein PrecursorsCase-Control StudiesChildChild, PreschoolFatty Acid-Binding ProteinsFemaleHumansInfantBiomarkersCholera ToxinFABP2 protein, humanFatty Acid-Binding ProteinsHaptoglobinsLeukocyte L1 Antigen ComplexProtein Precursorszonulincalprotectincerebral palsyIFABPinflammationpermeabilityzonulin

Identifiers

PMID39125328
PMCPMC11314602

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.