Experimental and In Silico Comparative Study of Physicochemical Properties and Antimicrobial Activity of Carboxylate Ionic Liquids.

Nikolett Cakó Bagány, Eleonora Čapelja, Strahinja Kovačević, Maja Karaman, Sanja Podunavac-Kuzmanović, Slobodan Gadžurić, Sanja Belić

Abstract readComparative Study

PubMed Full text at PMC Publisher

In one paragraph

Article in Molecules (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it

0cells of the map it votes in

2citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

Insights into the antimicrobial and antibiofilm activities of ionic liquids and their mechanisms of action.Applied microbiology and biotechnology · 2026
Review
1-Butyl-3-methylimidazolium Mandelate: A Multifunctional Ionic Liquid with Enhanced Hydrogen Bonding, Thermal Stability, Antimicrobial Activity, and Extraction Capability.Molecules (Basel, Switzerland) · 2025
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Nikolett Cakó BagányFaculty of Science, University of Novi Sad, Trg D. Obradovića 3, 21000 Novi Sad, Serbia.ORCID 0000-0003-2554-789X

Eleonora ČapeljaFaculty of Science, University of Novi Sad, Trg D. Obradovića 3, 21000 Novi Sad, Serbia.

Strahinja KovačevićFaculty of Technology, University of Novi Sad, Bulevar Cara Lazara 1, 21000 Novi Sad, Serbia.ORCID 0000-0002-5619-9894

Maja KaramanFaculty of Science, University of Novi Sad, Trg D. Obradovića 3, 21000 Novi Sad, Serbia.ORCID 0000-0002-8788-9206

Sanja Podunavac-KuzmanovićFaculty of Technology, University of Novi Sad, Bulevar Cara Lazara 1, 21000 Novi Sad, Serbia.

Slobodan GadžurićFaculty of Science, University of Novi Sad, Trg D. Obradovića 3, 21000 Novi Sad, Serbia.ORCID 0000-0002-8145-5239

Sanja BelićFaculty of Science, University of Novi Sad, Trg D. Obradovića 3, 21000 Novi Sad, Serbia.ORCID 0000-0002-1790-4298

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The COVID-19 pandemic highlighted the need to create and study new substances with improved lipophilicity and antimicrobial properties, such as ionic liquids (ILs), with easily tunable physicochemical properties. Most ILs possess strong antibacterial effects, but ILs containing the imidazolium cation are even more effective than the positive control. Thus, in this study, three ionic liquids with 1-butyl-3-methylimidazolium cation and various carboxylate anions (phenylacetate, benzoate, and 4-methoxyphenylacetate) were synthesized and fully characterized. The interactions between the cations and anions were discussed based on the experimental density, viscosity, and electrical conductivity. From the measured electrical conductivity and viscosity, the Walden plot is constructed and ionicity of the studied ILs is discussed. The similarities and dissimilarities among the studied ILs and their physicochemical properties are analyzed by applying the hierarchical cluster analysis and in silico calculated properties. The antimicrobial activity of the studied ionic liquids is tested on two bacterial (

Indexed as

Anti-Infective AgentsCarboxylic AcidsIonic LiquidsAnti-Bacterial AgentsComputer SimulationCOVID-19Electric ConductivityEscherichia coliImidazolesMicrobial Sensitivity TestsViscosity1-butyl-3-methylimidazoliumAnti-Bacterial AgentsAnti-Infective AgentsCarboxylic AcidsImidazolesIonic Liquidsantimicrobial activitydensityelectrical conductivityHCAionic liquidsviscosity

Identifiers

PMID39125070

DOI10.3390/molecules29153668

PMCPMC11314197

What OpenQuestion holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.