An Innovative Aggregation-Induced Emission-Based NIR Fluorescent Probe for Visualizing Carboxylesterases in Living Cells, Zebrafish, and Tumor-Bearing Mice.

Chao Gao, Dan-Dan Chen, Hu-Wei Liu, Ming-Lan Ma, Lin Zhang, Hai-Rong Cui

Abstract read

In one paragraph

Article in Molecules (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

6 authors.

Chao GaoSynergy Innovation Centre of Biological Peptide Antidiabetics of Hubei Province, College of Life Science, Wuchang University of Technology, Wuhan 430223, China.

Dan-Dan ChenSynergy Innovation Centre of Biological Peptide Antidiabetics of Hubei Province, College of Life Science, Wuchang University of Technology, Wuhan 430223, China.

Hu-Wei LiuSynergy Innovation Centre of Biological Peptide Antidiabetics of Hubei Province, College of Life Science, Wuchang University of Technology, Wuhan 430223, China.ORCID 0000-0001-6540-9657

Ming-Lan MaSynergy Innovation Centre of Biological Peptide Antidiabetics of Hubei Province, College of Life Science, Wuchang University of Technology, Wuhan 430223, China.

Lin ZhangSynergy Innovation Centre of Biological Peptide Antidiabetics of Hubei Province, College of Life Science, Wuchang University of Technology, Wuhan 430223, China.

Hai-Rong CuiSynergy Innovation Centre of Biological Peptide Antidiabetics of Hubei Province, College of Life Science, Wuchang University of Technology, Wuhan 430223, China.

Funding

National Natural Science Foundation of China 22174100

6 · The paper itself

Abstract

In the human body, carboxylesterases (CEs) play crucial roles in xenobiotic metabolism and lipid homeostasis. But abnormal expression of CEs is highly associated with some diseases, such as hyperlipidemia, diabetes, and liver cancer. Therefore, it is of great importance to develop an efficient tool for the accurate detection of CEs in living organisms. Herein, an innovative near-infrared (NIR) fluorescent probe,

Indexed as

Carboxylic Ester HydrolasesFluorescent DyesZebrafishAnimalsCell Line, TumorHumansLiver NeoplasmsMiceOptical ImagingCarboxylic Ester HydrolasesFluorescent Dyesaggregation-induced emissionbioimagingcarboxylesterasesNIR fluorescent probe

Identifiers

PMID39125064

DOI10.3390/molecules29153660

PMCPMC11314084

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