Evidence map›Paper›PMID 39125051›Full record

ArticleMolecules (Basel, Switzerland)2024

Design, Synthesis, and Biological Evaluations of Novel Thiazolo[4,5-d]pyrimidine Corticotropin Releasing Factor (CRF) Receptor Antagonists as Potential Treatments for Stress Related Disorders and Congenital Adrenal Hyperplasia (CAH).

Md Rabiul Islam, Christos Markatos, Ioannis Pirmettis, Minas Papadopoulos, Vlasios Karageorgos, George Liapakis, Hesham Fahmy

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecules (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Md Rabiul IslamDepartment of Pharmaceutical Science, College of Pharmacy & Allied Health Professions, South Dakota State University, Brookings, SD 57007, USA.
Christos MarkatosDepartment of Pharmacology, School of Medicine, University of Crete, Heraklion, 71003 Crete, Greece.ORCID 0009-0001-9386-7169
Ioannis PirmettisInstitute of Nuclear & Radiological Sciences & Technology, Energy & Safety, National Centre for Scientific Research "Demokritos", 15310 Athens, Greece.ORCID 0000-0003-4933-7723
Minas PapadopoulosInstitute of Nuclear & Radiological Sciences & Technology, Energy & Safety, National Centre for Scientific Research "Demokritos", 15310 Athens, Greece.
Vlasios KarageorgosDepartment of Pharmacology, School of Medicine, University of Crete, Heraklion, 71003 Crete, Greece.ORCID 0000-0001-7380-9677
George LiapakisDepartment of Pharmacology, School of Medicine, University of Crete, Heraklion, 71003 Crete, Greece.ORCID 0000-0003-2423-3135
Hesham FahmyDepartment of Pharmaceutical Science, College of Pharmacy & Allied Health Professions, South Dakota State University, Brookings, SD 57007, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Corticotropin-releasing factor (CRF) is a key neuropeptide hormone that is secreted from the hypothalamus. It is the master hormone of the HPA axis, which orchestrates the physiological and behavioral responses to stress. Many disorders, including anxiety, depression, addiction relapse, and others, are related to over-activation of this system. Thus, new molecules that may interfere with CRF receptor binding may be of value to treat neuropsychiatric stress-related disorders. Also, CRF

Indexed as

Adrenal Hyperplasia, CongenitalDrug DesignPyrimidinesReceptors, Corticotropin-Releasing HormoneCorticotropin-Releasing HormoneCRF Receptor, Type 1HumansMolecular Docking SimulationPyrrolesStress, PsychologicalantalarminCorticotropin-Releasing HormoneCRF Receptor, Type 1PyrimidinesPyrrolesReceptors, Corticotropin-Releasing Hormoneantalarmincongenital adrenal hyperplasia (CAH)CRF receptor antagoniststhiazolo[4,5-d]pyrimidines

Identifiers

PMID39125051
PMCPMC11314199

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.