Evidence map›Paper›PMID 39124952›Full record

ArticleMolecules (Basel, Switzerland)2024

Inhibition of DNA Topoisomerase Ι by Flavonoids and Polyacetylenes Isolated from

Guiyuan Zeng, Yinyue Wang, Meihua Zhu, Jumei Yi, Junjie Ma, Bijuan Yang, Weiqing Sun, Fang Dai, Junlin Yin, Guangzhi Zeng

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecules (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Potential Relevance ofDrug design, development and therapy · 2026
    Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Guiyuan ZengKey Laboratory of Chemistry in Ethnic Medicinal Resources, State Ethnic Affairs Commission and Ministry of Education, Yunnan Minzu University, Kunming 650504, China.
Yinyue WangKey Laboratory of Chemistry in Ethnic Medicinal Resources, State Ethnic Affairs Commission and Ministry of Education, Yunnan Minzu University, Kunming 650504, China.
Meihua ZhuKey Laboratory of Chemistry in Ethnic Medicinal Resources, State Ethnic Affairs Commission and Ministry of Education, Yunnan Minzu University, Kunming 650504, China.
Jumei YiKey Laboratory of Chemistry in Ethnic Medicinal Resources, State Ethnic Affairs Commission and Ministry of Education, Yunnan Minzu University, Kunming 650504, China.
Junjie MaKey Laboratory of Chemistry in Ethnic Medicinal Resources, State Ethnic Affairs Commission and Ministry of Education, Yunnan Minzu University, Kunming 650504, China.
Bijuan YangKey Laboratory of Chemistry in Ethnic Medicinal Resources, State Ethnic Affairs Commission and Ministry of Education, Yunnan Minzu University, Kunming 650504, China.
Weiqing SunKey Laboratory of Chemistry in Ethnic Medicinal Resources, State Ethnic Affairs Commission and Ministry of Education, Yunnan Minzu University, Kunming 650504, China.
Fang DaiSchool of Chemistry and Environmental Engineering, Qujing Normal University, Qujing 655011, China.
Junlin YinKey Laboratory of Chemistry in Ethnic Medicinal Resources, State Ethnic Affairs Commission and Ministry of Education, Yunnan Minzu University, Kunming 650504, China.
Guangzhi ZengKey Laboratory of Chemistry in Ethnic Medicinal Resources, State Ethnic Affairs Commission and Ministry of Education, Yunnan Minzu University, Kunming 650504, China.

Funding

National Natural Science Foundation of China 81960639Project of Yunnan Provincial Department of Science and Technology 202205AC160084, 202401BC070018, 202402AN360010
6 · The paper itself

Abstract

Human DNA topoisomerase I (Topo I) is an essential enzyme in regulating DNA supercoiling during transcription and replication, and it is an important therapeutic target for anti-tumor agents.

Indexed as

BidensDNA Topoisomerases, Type IFlavonoidsPolyynesTopoisomerase I InhibitorsAntineoplastic Agents, PhytogenicCell Line, TumorHumansPlant ExtractsAntineoplastic Agents, PhytogenicDNA Topoisomerases, Type IFlavonoidsPlant ExtractsPolyynesTopoisomerase I InhibitorsBidens pilosa L.cytotoxicityDNA topoisomerase Iflavonoidspolyacetylenesstructure–activity analysis

Identifiers

PMID39124952
PMCPMC11314063

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.