Evidence map›Paper›PMID 39124924›Full record

ReviewMolecules (Basel, Switzerland)2024

Advanced Application of Polymer Nanocarriers in Delivery of Active Ingredients from Traditional Chinese Medicines.

Zhiyuan Zhai, Jianda Niu, Liguo Xu, Jinbao Xu

Abstract readReview
In one paragraph

Review in Molecules (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Review
  5. Review
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Zhiyuan ZhaiSchool of Materials and Energy, Guangdong University of Technology, Guangzhou 510006, China.
Jianda NiuSchool of Materials and Energy, Guangdong University of Technology, Guangzhou 510006, China.
Liguo XuCollege of Light Chemical Industry and Materials Engineering, Shunde Polytechnic, Foshan 528333, China.ORCID 0000-0002-3426-6208
Jinbao XuSchool of Materials and Energy, Guangdong University of Technology, Guangzhou 510006, China.ORCID 0000-0003-2008-0469

Funding

Natural Science Foundation of Guangdong Province 2022A1515010624
6 · The paper itself

Abstract

Active ingredients from Traditional Chinese Medicines (TCMs) have been a cornerstone of healthcare for millennia, offering a rich source of bioactive compounds with therapeutic potential. However, the clinical application of TCMs is often limited by challenges such as poor solubility, low bioavailability, and variable pharmacokinetics. To address these issues, the development of advanced polymer nanocarriers has emerged as a promising strategy for the delivery of TCMs. This review focuses on the introduction of common active ingredients from TCMs and the recent advancements in the design and application of polymer nanocarriers for enhancing the efficacy and safety of TCMs. We begin by discussing the unique properties of TCMs and the inherent challenges associated with their delivery. We then delve into the types of polymeric nanocarriers, including polymer micelles, polymer vesicles, polymer hydrogels, and polymer drug conjugates, highlighting their application in the delivery of active ingredients from TCMs. The main body of the review presents a comprehensive analysis of the state-of-the-art nanocarrier systems and introduces the impact of these nanocarriers on the solubility, stability, and bioavailability of TCM components. On the basis of this, we provide an outlook on the future directions of polymer nanocarriers in TCM delivery. This review underscores the transformative potential of polymer nanocarriers in revolutionizing TCM delivery, offering a pathway to harness the full therapeutic potential of TCMs while ensuring safety and efficacy in a modern medical context.

Indexed as

Drug CarriersDrugs, Chinese HerbalMedicine, Chinese TraditionalNanoparticlesPolymersAnimalsBiological AvailabilityDrug Delivery SystemsHumansMicellesDrug CarriersDrugs, Chinese HerbalMicellesPolymersdrug deliverypolymer drug conjugatespolymer hydrogelspolymer micellespolymer vesiclesTraditional Chinese Medicines

Identifiers

PMID39124924
PMCPMC11314021

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.