Evidence map›Paper›PMID 39123618›Full record

ArticleFoods (Basel, Switzerland)2024

Increased Levels of Phosphorylated-P38α Induce WNT/β-Catenin and NGF/P75NTR/TrkA Pathways Disruption and SN56 Cell Death following Single and Repeated Chlorpyrifos Treatment.

Paula Moyano, Andrea Flores, María de la Cabeza Fernández, Jimena García, Javier Sanjuan, José Carlos Plaza, Javier Del Pino

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Foods (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Paula MoyanoPharmacology and Toxicology Department, Veterinary School, Complutense University, 28040 Madrid, Spain.ORCID 0000-0002-6621-623X
Andrea FloresPharmacology and Toxicology Department, Veterinary School, Complutense University, 28040 Madrid, Spain.ORCID 0000-0003-2228-1678
María de la Cabeza FernándezChemistry in Chemical Sciences Department, Pharmacy School, Complutense University, 28040 Madrid, Spain.
Jimena GarcíaPharmacology and Toxicology Department, Veterinary School, Complutense University, 28040 Madrid, Spain.
Javier SanjuanPharmacology and Toxicology Department, Veterinary School, Complutense University, 28040 Madrid, Spain.
José Carlos PlazaLegal Medicine, Psychiatry and Pathology Department, Medicine School, Complutense University, 28040 Madrid, Spain.ORCID 0000-0001-9911-4814
Javier Del PinoPharmacology and Toxicology Department, Veterinary School, Complutense University, 28040 Madrid, Spain.ORCID 0000-0001-6937-7701

Funding

Alborada Foundation/Catedra Extradordinaria de Patologia y Medioambiente, UCM 172C126PMASantander Bank/UCM PR26/20326
6 · The paper itself

Abstract

Chlorpyrifos (CPF) biocide, exposure to which is mainly produced in the human population through diet, induces several neurotoxic effects. CPF single and repeated exposure induces memory and learning disorders, although the mechanisms that produce these outcomes are complex and not well understood. CPF treatment (single and repeated) of cholinergic septal SN56 cells induced an increase in phosphorylated-P38α levels that led to WNT/β-Catenin and NGF/P75

Indexed as

basal forebrain cholinergic neuronschlorpyrifosNGF/P75NTR/TrkA pathwayP38αWNT/β-Catenin pathway

Identifiers

PMID39123618
PMCPMC11311586

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.