Evidence map›Paper›PMID 39123149›Full record

ArticleBMC pediatrics2024

Non-invasive neurally adjusted ventilatory assist (NIV-NAVA) in the neonatal intensive care unit (NICU): an Australian NICU experience.

Jonathan Cheng, Trisha Parmar, John Smyth, Srivinas Bolisetty, Kei Lui, Tim Schindler

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Article in BMC pediatrics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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5 · Who and what money

Authors and funding

6 authors.

Jonathan ChengUniversity of New South Wales, Sydney, NSW, 2032, Australia.
Trisha ParmarDepartment of Newborn Care, Royal Hospital for Women, Barker St, Randwick, NSW, 2031, Australia.
John SmythUniversity of New South Wales, Sydney, NSW, 2032, Australia.
Srivinas BolisettyUniversity of New South Wales, Sydney, NSW, 2032, Australia.
Kei LuiUniversity of New South Wales, Sydney, NSW, 2032, Australia.
Tim SchindlerUniversity of New South Wales, Sydney, NSW, 2032, Australia. tim.schindler@health.nsw.gov.au.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPreterm infants often require non-invasive breathing support while their lungs and control of respiration are still developing. Non-invasive neurally adjusted ventilatory assist (NIV-NAVA) is an emerging technology that allows infants to breathe spontaneously while receiving support breaths proportional to their effort. This study describes the first Australian Neonatal Intensive Care Unit (NICU) experience of NIV-NAVA.

methodsRetrospective cohort study of infants admitted to a major tertiary NICU between October 2017 and April 2021 supported with NIV-NAVA. Infants were divided into three groups based on the indication to initiate NIV-NAVA (post-extubation; apnoea; escalation). Successful application of NIV-NAVA was based on the need for re-intubation within 48 h of application.

resultsThere were 169 NIV-NAVA episodes in 122 infants (82 post-extubation; 21 apnoea; 66 escalation). The median (range) gestational age at birth was 25 + 5 weeks (23 + 1 to 43 + 3 weeks) and median (range) birthweight was 963 g (365-4320 g). At NIV-NAVA application, mean (SD) age was 17 days (18.2), and median (range) weight was 850 g (501-4310 g). Infants did not require intubation within 48 h in 145/169 (85.2%) episodes [72/82 (87.8%) extubation; 21/21 (100%) apnoea; 52/66 (78.8%) escalation).

conclusionNIV-NAVA was successfully integrated for the three main indications (escalation; post-extubation; apnoea). Prospective clinical trials are still required to establish its effectiveness versus other modes of non-invasive support.

Indexed as

Intensive Care Units, NeonatalInteractive Ventilatory SupportNoninvasive VentilationAirway ExtubationApneaAustraliaFemaleHumansInfant, NewbornInfant, PrematureMaleRespiratory Distress Syndrome, NewbornRetrospective StudiesInteractive ventilatory supportNeurally adjusted ventilatory assistNon-invasive ventilationPremature infantVentilation weaning

Identifiers

PMID39123149
PMCPMC11312715

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.