Trial reportBMC anesthesiology2024
Differential response to preoperative exercise training in patients candidates to cardiac valve replacement.
Trial report in BMC anesthesiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03466606 (Implementation of a Trimodal Prehabilitation Program as a Preoperative Optimization Strategy in Cardiac Surgery), which is not on this map. Cited by 6 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Implementation of a Trimodal Prehabilitation Program as a Preoperative Optimization Strategy in Cardiac Surgery
Who cites it
6 citing papers in PubMed.
- Adherence, Compliance Rates, and Response to Training Among Patients Awaiting Colorectal Cancer Surgery: A Secondary Analysis From the PREHAB Multicentre Trial.Annals of surgical oncology · 2026Article
- Impact of prehabilitation on patient-perceived quality of recovery after surgery: prospective cohort study.BJS open · 2025Article
- Dose-Response Effect of Physical Prehabilitation on Major Cardiac and Cerebrovascular Events and Disability Levels After Cardiac Surgery in Frail Patients.CHEST pulmonary · 2025Article
- Exercise-Based Prehabilitation Before Cardiac Surgery: A Systematic Review, Meta-Analysis, Meta-Regression, and Proposal for a Clinical Implementation Model.Journal of clinical medicine · 2025Review
- Implementing Cardiac Prehabilitation in Brazil: Building an Evidence-based Framework for Surgical Outcomes.Arquivos brasileiros de cardiologia · 2025Review
- Cardiac Rehabilitation After Mitral Valve Intervention: Tailored Assessment, Management, and Exercise Training.Journal of cardiovascular development and disease · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
Abstract
backgroundThere is lack of evidence regarding safety, effectiveness and applicability of prehabilitation on cardiac surgery population, particularly in patients candidates to cardiac valve replacement. The aim of the study is to assess and compare the effect of a multimodal prehabilitation program on functional capacity in patients with severe aortic stenosis (AoS) and severe mitral regurgitation (MR) proposed for valve replacement surgery.
methodsSecondary analysis from a randomised controlled trial whose main objective was to analyze the efficacy of a 4-6 weeks multimodal prehabilitation program in cardiac surgery on reducing postoperative complications. For this secondary analysis, only candidates for valve replacement surgery were selected. The primary outcome was the change in endurance time (ET) from baseline to preoperative assessment measured by a cycling constant work-rate cardiopulmonary exercise test.
results68 patients were included in this secondary analysis, 34 (20 AoS and 14 MR) were allocated to the prehabilitation group and 34 (20 AoS and 14 MR) to control group. At baseline, patients with AoS had better left systolic ventricular function and lower prevalence of atrial fibrillation compared to MR (p = 0.022 and p = 0.035 respectively). After prehabilitation program, patients with MR showed greater improvement in ET than AoS patients (101% vs. 66% increase from baseline). No adverse events related to the prehabilitation program were observed.
conclusionsA 4-6 week exercise training program is safe and overall improves functional capacity in patients with severe AoS and MR. However, exercise response is different according to the cardiac valve type disfunction, and further studies are needed to know the factors that predispose some patients to have better training response.
trial registrationThe study has been registered on the Registry of National Institutes of Health ClinicalTrials.gov (NCT03466606) (05/03/2018).
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.