Evidence map›Paper›PMID 39123082›Full record

ReviewPediatric radiology2024

FDG-PET/MRI in the presurgical evaluation of pediatric epilepsy.

Maria R Ponisio, John M Zempel, Jon T Willie, Stuart R Tomko, Sean D McEvoy, Jarod L Roland, Jonathan P Williams

Abstract readReview
PubMed Publisher
In one paragraph

Review in Pediatric radiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Maria R PonisioDivision of Nuclear Medicine, Mallinckrodt Institute of Radiology, School of Medicine, Washington University in St Louis, MSC 8223-0019-10, 510 S. Kingshighway Blvd, St. Louis, MO, 63110, USA. mrponisio@wustl.edu.ORCID http://orcid.org/0000-0002-4528-8971
John M ZempelDepartment of Neurology, School of Medicine, Washington University in St Louis, St. Louis, MO, USA.
Jon T WillieDepartment of Neurosurgery, School of Medicine, Washington University in St Louis, St. Louis, MO, USA.
Stuart R TomkoDepartment of Neurology, School of Medicine, Washington University in St Louis, St. Louis, MO, USA.
Sean D McEvoyDepartment of Neurosurgery, School of Medicine, Washington University in St Louis, St. Louis, MO, USA.
Jarod L RolandDepartment of Neurosurgery, School of Medicine, Washington University in St Louis, St. Louis, MO, USA.
Jonathan P WilliamsDepartment of Neurology, School of Medicine, Washington University in St Louis, St. Louis, MO, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In patients with drug-resistant epilepsy, difficulties in identifying the epileptogenic zone are well known to correlate with poorer clinical outcomes post-surgery. The integration of PET and MRI in the presurgical assessment of pediatric patients likely improves diagnostic precision by confirming or widening treatment targets. PET and MRI together offer superior insights compared to either modality alone. For instance, PET highlights abnormal glucose metabolism, while MRI precisely localizes structural anomalies, providing a comprehensive understanding of the epileptogenic zone. Furthermore, both methodologies, whether utilized through simultaneous PET/MRI scanning or the co-registration of separately acquired PET and MRI data, present unique advantages, having complementary roles in lesional and non-lesional cases. Simultaneous FDG-PET/MRI provides precise co-registration of functional (PET) and structural (MR) imaging in a convenient one-stop-shop approach, which minimizes sedation time and reduces radiation exposure in children. Commercially available fusion software that allows retrospective co-registration of separately acquired PET and MRI images is a commonly used alternative. This review provides an overview and illustrative cases that highlight the role of combining 18F-FDG-PET and MRI imaging and shares the authors' decade-long experience utilizing simultaneous PET/MRI in the presurgical evaluation of pediatric epilepsy.

Indexed as

EpilepsyFluorodeoxyglucose F18Magnetic Resonance ImagingPositron-Emission TomographyPreoperative CareRadiopharmaceuticalsAdolescentChildChild, PreschoolDrug Resistant EpilepsyFemaleHumansMaleMultimodal ImagingFluorodeoxyglucose F18Radiopharmaceuticals18F-FDG-PETDrug-resistant epilepsyMRIPediatric epilepsyPET/MRIPresurgical evaluation

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.