ArticleThe EMBO journal2024
Modular control of vertebrate axis segmentation in time and space.
Article in The EMBO journal, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
7 citing papers in PubMed.
- Cycles upon cycles-Temperature scaling of medaka development.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Genetic basis of latitudinal variation in vertebral number in the Oryzias latipes species complex.Zoological letters · 2025Article
- Evolvability in vertebrate segmentation.Seminars in cell & developmental biology · 2025Review
- Progress in understanding the vertebrate segmentation clock.Nature reviews. Genetics · 2025Review
- Natural genetic variation quantitatively regulates heart rate and dimension.Nature communications · 2025Article
- The stem cell zoo for comparative studies of developmental tempo.Current opinion in genetics & development · 2024Review
- Species-specific roles of the Notch ligands, receptors, and targets orchestrating the signaling landscape of the segmentation clock.Frontiers in cell and developmental biology · 2023Review
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
How the timing of development is linked to organismal size is a longstanding question. Although numerous studies have reported a correlation of temporal and spatial traits, the developmental or selective constraints underlying this link remain largely unexplored. We address this question by studying the periodic process of embryonic axis segmentation in-vivo in Oryzias fish. Interspecies comparisons reveal that the timing of segmentation correlates to segment, tissue and organismal size. Segment size in turn scales according to tissue and organism size. To probe for underlying causes, we genetically hybridised two closely related species. Quantitative analysis in ~600 phenotypically diverse F2 embryos reveals a decoupling of timing from size control, while spatial scaling is preserved. Using developmental quantitative trait loci (devQTL) mapping we identify distinct genetic loci linked to either the control of segmentation timing or tissue size. This study demonstrates that a developmental constraint mechanism underlies spatial scaling of axis segmentation, while its spatial and temporal control are dissociable modules.
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Registered trials
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