Evidence map›Paper›PMID 39122895›Full record

ArticleJournal of molecular histology2024

A triterpenoid (corosolic acid) ameliorated AOM-mediated aberrant crypt foci in rats: modulation of Bax/PCNA, antioxidant and inflammatory mechanisms.

Morteta H Al-Medhtiy, Mohammed T Mohammed, Mohammed M Hussein M Raouf, Ayman M Al-Qaaneh, Ahmed A J Jabbar, Fuad Othman Abdullah, Ramzi A Mothana, Abdullah R Alanzi, Rawaz Rizgar Hassan, Mahmood Ameen Abdulla and 2 more

Abstract read
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In one paragraph

Article in Journal of molecular histology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
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  5. A Traditional Gum Exudate FromFood science & nutrition · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Morteta H Al-MedhtiyDepartment of Anatomy and Histology, Faculty of Veterinary Medicine, University of Kufa, Kufa, Najaf Region, 540011, Iraq.
Mohammed T MohammedDepartment of Microbiology, Faculty of veterinary medicine, University of Kufa, Kufa, Iraq.
Mohammed M Hussein M RaoufDepartment of Biomedical Sciences, College of Applied Science, Cihan University-Erbil, Erbil, Kurdistan Region, 44001, Iraq.
Ayman M Al-QaanehDepartment of Allied Health Sciences, Al-Balqa Applied University (BAU), Al-Salt, 19117, Jordan.
Ahmed A J JabbarDepartment of Medical Laboratory Technology, Erbil Technical Health and Medical College, Erbil Polytechnic University, Erbil, 44001, Iraq. ahmed.abuljabbar@epu.edu.iq.
Fuad Othman AbdullahDepartment of Chemistry, College of Science, Salahaddin University-Erbil, Erbil, Kurdistan Region, Iraq.
Ramzi A MothanaDepartment of Pharmacognosy, College of Pharmacy, King Saud University, P.O. Box 2457, Riyadh, 11451, Saudi Arabia.
Abdullah R AlanziDepartment of Pharmacognosy, College of Pharmacy, King Saud University, P.O. Box 2457, Riyadh, 11451, Saudi Arabia.
Rawaz Rizgar HassanDepartment of Medical Laboratory Science, College of Science, Knowledge University, Kirkuk Road, Erbil, 44001, Iraq.
Mahmood Ameen AbdullaDepartment of Medical Analysis, Faculty of Applied Science, Tishk International University, Erbil, Iraq.
Musher Ismail SalehDepartment of Chemistry, Faculty of Science and Health, Koya University, Koya KOY45, Kurdistan Region, Erbil, 44001, Iraq.
Sidgi HassonSchool of Pharmacy and Biomolecular Sciences, Liverpool John Moores University, Liverpool, L3 3AF, UK.

Funding

Funding: The Research was funded by the Researchers Supporting Project program (RSP2024R119), King Saud University, Riyadh, Saudi Arabia. (RSP2024R119)
6 · The paper itself

Abstract

Corosolic acid (CA) is a well-known natural pentacyclic triterpene found in numerous therapeutic plants that can exhibit many bioactivities including anti-inflammatory and anti-tumor actions. The current investigation explores the chemoprotective roles of CA against azoxymethane (AOM)-induced colonic aberrant crypt foci (ACF) in rats. Thirty Sprague Dawley rats were grouped in 5 cages; Group A, normal control rats inoculated subcutaneously (sc) with two doses of normal saline and fed orally on 10% tween 20; Groups B-E received two doses (sc) of azoxymethane in two weeks and treated with either 10% tween 20 (group B) or two intraperitoneal injections of 35 mg/kg 5-fluorouracil each week for one month (group C), while group D and E treated with 30 and 60 mg/kg, respectively, for 2 months. The toxicity results showed lack of any behavioral abnormalities or mortality in rats ingested with up-to 500 mg/kg of CA. The present AOM induction caused a significant initiation of ACF characterized by an increased number, larger in size, and well-matured tissue clusters in cancer controls. AOM inoculation created a bizarrely elongated nucleus, and strained cells, and significantly lowered the submucosal glands in colon tissues of cancer controls compared to 5-FU or CA-treated rats. CA treatment led to significant suppression of ACF incidence, which could be mediated by its modulatory effects on the immunohistochemical proteins (pro-apoptotic (Bax) and reduced PCNA protein expressions in colon tissues). Moreover, CA-treated rats had improved oxidative stress-mediated cytotoxicity indicated by increased endogenous antioxidants (SOD and CAT) and reduced lipid peroxidation indicators (MDA). In addition, CA ingestion (30 and 60 mg/kg) suppressed the inflammatory cascades, indicated by decreased serum TNF-α and IL-6 cytokines and increased anti-inflammatory (IL-10) cytokines consequently preventing further tumor development. CA treatment maintained liver and kidney functions in rats exposed to AOM cytotoxicity. CA could be a viable alternative for the treatment of oxidative-related human disorders including ACF.

Indexed as

Aberrant Crypt FociAntioxidantsAzoxymethanebcl-2-Associated X ProteinProliferating Cell Nuclear AntigenRats, Sprague-DawleyTriterpenesAnimalsColonInflammationMaleOxidative StressRatsAntioxidantsAzoxymethanebcl-2-Associated X Proteincorosolic acidProliferating Cell Nuclear AntigenTriterpenesAberrant crypt fociAnd IL-10)Colon cancerCorosolic acidIL-6Immunohistochemistry (Bax and PCNA)Inflammatory cytokines (TNF-α

Identifiers

PMID39122895

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.