Evidence map›Paper›PMID 39122799›Full record

ArticleScientific reports2024

Multi-omics analysis of antiviral interactions of Elizabethkingia anophelis and Zika virus.

S Omme, J Wang, M Sifuna, J Rodriguez, N R Owusu, M Goli, P Jiang, P Waziha, J Nwaiwu, C L Brelsfoard and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

S OmmeDepartment of Biological Sciences, Texas Tech University, 2901 Main St, Lubbock, TX, 79409, USA.
J WangDepartment of Biochemistry and Chemistry, Texas Tech University, 2901 Main St, Lubbock, TX, 79409, USA.
M SifunaDepartment of Biological Sciences, Texas Tech University, 2901 Main St, Lubbock, TX, 79409, USA.
J RodriguezDepartment of Biological Sciences, Texas Tech University, 2901 Main St, Lubbock, TX, 79409, USA.
N R OwusuDepartment of Biological Sciences, Texas Tech University, 2901 Main St, Lubbock, TX, 79409, USA.
M GoliDepartment of Biochemistry and Chemistry, Texas Tech University, 2901 Main St, Lubbock, TX, 79409, USA.
P JiangDepartment of Biochemistry and Chemistry, Texas Tech University, 2901 Main St, Lubbock, TX, 79409, USA.
P WazihaDepartment of Biochemistry and Chemistry, Texas Tech University, 2901 Main St, Lubbock, TX, 79409, USA.
J NwaiwuDepartment of Biochemistry and Chemistry, Texas Tech University, 2901 Main St, Lubbock, TX, 79409, USA.
C L BrelsfoardDepartment of Biological Sciences, Texas Tech University, 2901 Main St, Lubbock, TX, 79409, USA.
A VigneronLaboratoire d'Ecologie Microbienne, Claude Bernard University Lyon, University of Lyon, Lyon, France.
A T CiotaWadsworth Centre, New York State Department of Health, Griffin Laboratory, 5668 State Farm Road, Slingerlands, NY, 12159, USA.
L D KramerSchool of Public Health, State University of New York Albany, 1400 Washington Avenue, Albany, NY, 12222, USA.
Y MechrefDepartment of Biochemistry and Chemistry, Texas Tech University, 2901 Main St, Lubbock, TX, 79409, USA.
M G OnyangosDepartment of Biological Sciences, Texas Tech University, 2901 Main St, Lubbock, TX, 79409, USA. maonyang@ttu.edu.

Funding

Quantitative Characterization of Glycopeptide IsomersR01GM130091 · NIGMS · TEXAS TECH UNIVERSITY · PI Yehia Mechref · 2019 to 2026
$2.5M
National Institute of Health, NIAID 1R01GM130091-04NIGMS NIH HHS R01 GM130091
6 · The paper itself

Abstract

The microbial communities residing in the mosquito midgut play a key role in determining the outcome of mosquito pathogen infection. Elizabethkingia anophelis, originally isolated from the midgut of Anopheles gambiae possess a broad-spectrum antiviral phenotype, yet a gap in knowledge regarding the mechanistic basis of its interaction with viruses exists. The current study aims to identify pathways and genetic factors linked to E. anophelis antiviral activity. The understanding of E. anophelis antiviral mechanism could lead to novel transmission barrier tools to prevent arboviral outbreaks. We utilized a non-targeted multi-omics approach, analyzing extracellular lipids, proteins, metabolites of culture supernatants coinfected with ZIKV and E. anophelis. We observed a significant decrease in arginine and phenylalanine levels, metabolites that are essential for viral replication and progression of viral infection. This study provides insights into the molecular basis of E. anophelis antiviral phenotype. The findings lay a foundation for in-depth mechanistic studies.

Indexed as

FlavobacteriaceaeZika VirusAnimalsAnophelesAntiviral AgentsArginineMultiomicsPhenylalanineVirus ReplicationZika Virus InfectionAntiviral AgentsArgininePhenylalanineAntiviral interactionsElizabethkingia anophelesMulti-omics analysisZika virus

Identifiers

PMID39122799
PMCPMC11315927

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.