Evidence map›Paper›PMID 39122784›Full record

ArticleNature metabolism2024

Broad-spectrum antibiotics disrupt homeostatic efferocytosis.

Pedro H V Saavedra, Alissa J Trzeciak, Allie Lipshutz, Andrew W Daman, Anya J O'Neal, Zong-Lin Liu, Zhaoquan Wang, Jesús E Romero-Pichardo, Waleska Saitz Rojas, Giulia Zago and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature metabolism, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed.

  1. Review
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  16. Review
  17. Review
  18. Efferocytosis in Homeostasis.Advances in experimental medicine and biology · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Pedro H V SaavedraImmunology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA. p.saavedra@northeastern.edu.ORCID http://orcid.org/0000-0002-7659-4533
Alissa J TrzeciakImmunology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA.ORCID http://orcid.org/0000-0002-4518-0098
Allie LipshutzImmunology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA.ORCID http://orcid.org/0000-0002-1786-7300
Andrew W DamanImmunology and Microbial Pathogenesis Program, Weill Cornell Medical College, Cornell University, New York, NY, USA.ORCID http://orcid.org/0000-0001-8144-0574
Anya J O'NealImmunology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA.ORCID http://orcid.org/0000-0001-5188-1344
Zong-Lin LiuImmunology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Zhaoquan WangImmunology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA.ORCID http://orcid.org/0000-0001-8227-0941
Jesús E Romero-PichardoImmunology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA.ORCID http://orcid.org/0000-0002-4400-5765
Waleska Saitz RojasImmunology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Giulia ZagoImmunology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Marcel R M van den BrinkImmunology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA.ORCID http://orcid.org/0000-0003-0696-4401
Steven Z JosefowiczImmunology and Microbial Pathogenesis Program, Weill Cornell Medical College, Cornell University, New York, NY, USA.
Christopher D LucasUniversity of Edinburgh Centre for Inflammation Research, Queen's Medical Research Institute, Edinburgh BioQuarter, UK.ORCID http://orcid.org/0000-0002-7523-0295
Christopher J AndersonInstitute for Regeneration and Repair, Edinburgh BioQuarter, UK.ORCID http://orcid.org/0000-0003-2600-0968
Alexander Y RudenskyImmunology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA.ORCID http://orcid.org/0000-0003-1280-2898
Justin S A PerryImmunology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA. perryj@mskcc.org.ORCID http://orcid.org/0000-0003-4063-6524

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Nicholas D Socci · 1985 to 2026
$347.4M
Structure, Function, and Dynamics of Macro-molecular Complexes that Execute and Regulate Genome FunctionRM1GM139738 · NIGMS · CORNELL UNIVERSITY · PI Thomas George Wade Graham, Steven Zvi Josefowicz · 2021 to 2026
$14.4M
Histone Variant H3.3 as a Transcription Rheostat in the Immune SystemR01AI148416 · NIAID · WEILL MEDICAL COLL OF CORNELL UNIV · PI Steven Zvi Josefowicz · 2020 to 2026
$4.6M
Rethinking the "quiet" nature of apoptotic cell clearance.DP2GM146337 · NIGMS · SLOAN-KETTERING INST CAN RESEARCH · PI PERRY, JUSTIN S · 2021 to 2024
$2.6M
Regulation of tumor-associated phagocyte physiology during tumor cell clearanceR00CA237728 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI PERRY, JUSTIN S · 2019 to 2021
$747k
Burroughs Wellcome Fund (BWF) PATHMedical Research Council MR/W019264/1Medical Research Council MR/X019314/1NCI NIH HHS P30 CA008748NCI NIH HHS R00 CA237728NIAID NIH HHS R01 AI148416NIGMS NIH HHS DP2 GM146337NIGMS NIH HHS RM1 GM139738RCUK | Medical Research Council (MRC) MR/W019264/1RCUK | Medical Research Council (MRC) MR/X019314/1U.S. Department of Health & Human Services | NIH | National Cancer Institute (NCI) 5R00CA237728U.S. Department of Health & Human Services | NIH | National Cancer Institute (NCI) P30CA008748U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases (NIAID) R01AI148416U.S. Department of Health & Human Services | NIH | National Institute of General Medical Sciences (NIGMS) RM1GM139738U.S. Department of Health & Human Services | NIH | NIH Office of the Director (OD) 1DP2GM146337Wellcome TrustWellcome Trust (Wellcome) 225923/Z/22/Z
6 · The paper itself

Abstract

The clearance of apoptotic cells, termed efferocytosis, is essential for tissue homeostasis and prevention of autoimmunity

Indexed as

Anti-Bacterial AgentsHomeostasisPhagocytosisAnimalsApoptosisButyratesEfferocytosisGastrointestinal MicrobiomeHumansMacrophagesMacrophages, PeritonealMembrane ProteinsMiceMice, Inbred C57BLAnti-Bacterial AgentsButyratesMembrane ProteinsTIM-4 protein, mouse

Identifiers

PMID39122784
PMCPMC7616532

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.