Evidence map›Paper›PMID 39122555›Full record

Trial reportLife science alliance2024

JAK inhibition with tofacitinib rapidly increases contractile force in human skeletal muscle.

Joseph B Shrager, Ryan Randle, Myung Lee, Syed Saadan Ahmed, Winston Trope, Natalie Lui, George Poultsides, Doug Liou, Brendan Visser, Jeffrey A Norton and 13 more

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Life science alliance, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03681275 (A Clinical Trial of JAK Inhibition to Prevent Ventilator-induced Diaphragm Dysfunction), which is not on this map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03681275 phase2recruitingnot on this map

A Clinical Trial of JAK Inhibition to Prevent Ventilator-induced Diaphragm Dysfunction

TypeinterventionalSponsorStanford UniversityRan2019 to 2026Enrolled70ConditionsDiaphragm InjuryArmsTofacitinib 10 MG [Xeljanz], Placebo to match Tofacitinib
3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors.

Joseph B ShragerDivision of Thoracic Surgery, Department of Cardiothoracic Surgery, Stanford University School of Medicine, Stanford, CA, USA shrager@stanford.edu.ORCID 0000-0003-0859-0589
Ryan RandleDivision of Thoracic Surgery, Department of Cardiothoracic Surgery, Stanford University School of Medicine, Stanford, CA, USA.
Myung LeeDivision of Thoracic Surgery, Department of Cardiothoracic Surgery, Stanford University School of Medicine, Stanford, CA, USA.
Syed Saadan AhmedDivision of Thoracic Surgery, Department of Cardiothoracic Surgery, Stanford University School of Medicine, Stanford, CA, USA.ORCID 0009-0006-1358-3438
Winston TropeDivision of Thoracic Surgery, Department of Cardiothoracic Surgery, Stanford University School of Medicine, Stanford, CA, USA.
Natalie LuiDivision of Thoracic Surgery, Department of Cardiothoracic Surgery, Stanford University School of Medicine, Stanford, CA, USA.
George PoultsidesDepartment of Surgery, Stanford University School of Medicine, Stanford, CA, USA.
Doug LiouDivision of Thoracic Surgery, Department of Cardiothoracic Surgery, Stanford University School of Medicine, Stanford, CA, USA.ORCID 0009-0006-9482-9216
Brendan VisserDepartment of Surgery, Stanford University School of Medicine, Stanford, CA, USA.
Jeffrey A NortonDepartment of Surgery, Stanford University School of Medicine, Stanford, CA, USA.
Shannon M NesbitDivision of Thoracic Surgery, Department of Cardiothoracic Surgery, Stanford University School of Medicine, Stanford, CA, USA.ORCID 0000-0001-6131-7982
Hao HeDivision of Thoracic Surgery, Department of Cardiothoracic Surgery, Stanford University School of Medicine, Stanford, CA, USA.ORCID 0000-0001-7029-6992
Ntemena KapulaDivision of Thoracic Surgery, Department of Cardiothoracic Surgery, Stanford University School of Medicine, Stanford, CA, USA.ORCID 0000-0002-4159-8913
Bailey WallenDivision of Thoracic Surgery, Department of Cardiothoracic Surgery, Stanford University School of Medicine, Stanford, CA, USA.ORCID 0009-0008-7180-6585
Emmanuel FatoduDivision of Thoracic Surgery, Department of Cardiothoracic Surgery, Stanford University School of Medicine, Stanford, CA, USA.
Cheyenne A SadeghiDivision of Thoracic Surgery, Department of Cardiothoracic Surgery, Stanford University School of Medicine, Stanford, CA, USA.ORCID 0000-0001-5018-2891
Harrison B KonskerDivision of Thoracic Surgery, Department of Cardiothoracic Surgery, Stanford University School of Medicine, Stanford, CA, USA.
Irmina ElliottDivision of Thoracic Surgery, Department of Cardiothoracic Surgery, Stanford University School of Medicine, Stanford, CA, USA.
Brandon GuenthartDivision of Thoracic Surgery, Department of Cardiothoracic Surgery, Stanford University School of Medicine, Stanford, CA, USA.ORCID 0000-0002-9864-0035
Leah BackhusDivision of Thoracic Surgery, Department of Cardiothoracic Surgery, Stanford University School of Medicine, Stanford, CA, USA.
Roger CookeDepartment of Biochemistry, University of California, San Francisco, CA, USA.
Mark BerryDivision of Thoracic Surgery, Department of Cardiothoracic Surgery, Stanford University School of Medicine, Stanford, CA, USA.ORCID 0000-0001-8680-7419
Huibin TangDivision of Thoracic Surgery, Department of Cardiothoracic Surgery, Stanford University School of Medicine, Stanford, CA, USA tanghb@stanford.edu.ORCID 0000-0002-9511-1963

Funding

A Mechanistic Clinical Trial of JAK Inhibition to Prevent Ventilator-induced Diaphragm DysfunctionR01HL148185 · NHLBI · STANFORD UNIVERSITY · PI BACKHUS, LEAH M, SHRAGER, JOSEPH B · 2019 to 2022
$1.9M
NHLBI NIH HHS R01 HL148185
6 · The paper itself

Abstract

Reduction in muscle contractile force associated with many clinical conditions incurs serious morbidity and increased mortality. Here, we report the first evidence that JAK inhibition impacts contractile force in normal human muscle. Muscle biopsies were taken from patients who were randomized to receive tofacitinib (n = 16) or placebo (n = 17) for 48 h. Single-fiber contractile force and molecular studies were carried out. The contractile force of individual diaphragm myofibers pooled from the tofacitinib group (n = 248 fibers) was significantly higher than those from the placebo group (n = 238 fibers), with a 15.7% greater mean maximum specific force (

Indexed as

Janus Kinase InhibitorsMuscle ContractionMuscle, SkeletalPiperidinesPyrimidinesAdultFemaleHumansJanus KinasesMaleMiddle AgedMuscle Fibers, SkeletalPyrrolesSignal TransductionJanus Kinase InhibitorsJanus KinasesPiperidinesPyrimidinesPyrrolestofacitinib

Identifiers

PMID39122555
PMCPMC11316201

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.