Evidence map›Paper›PMID 39122408›Full record

ArticleJournal of psychiatry & neuroscience : JPN

Emotional dysregulation and stimulant medication in adult ADHD.

Myrto Sklivanioti Greenfield, Yanlu Wang, J Paul Hamilton, Per Thunberg, Mussie Msghina

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of psychiatry & neuroscience : JPN. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Trial
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Myrto Sklivanioti GreenfieldFrom the Department of Clinical Neuroscience, Karolinska Institute, Stockholm, Sweden (Sklivanioti Greenfield, Msghina); the Department of Clinical Science, Intervention, and Technology, Karolinska Institute, Stockholm, Sweden (Wang); Medical Radiation Physics and Nuclear Medicine, Karolinska University Hospital, Stockholm, Sweden (Wang); the Department of Biological and Medical Psychology, University of Bergen, Norway (Hamilton); the Department for Radiology and Medical Physics, Faculty of Medicine and Health, Örebro University, Örebro, Sweden (Thunberg); the Center for Experimental and Biomedical Imaging in Örebro, Faculty of Medicine and Health, Örebro University, Örebro, Sweden (Thunberg); and the Department of Psychiatry, Faculty of Medicine and Health, Örebro University, Örebro, Sweden (Msghina).
Yanlu WangFrom the Department of Clinical Neuroscience, Karolinska Institute, Stockholm, Sweden (Sklivanioti Greenfield, Msghina); the Department of Clinical Science, Intervention, and Technology, Karolinska Institute, Stockholm, Sweden (Wang); Medical Radiation Physics and Nuclear Medicine, Karolinska University Hospital, Stockholm, Sweden (Wang); the Department of Biological and Medical Psychology, University of Bergen, Norway (Hamilton); the Department for Radiology and Medical Physics, Faculty of Medicine and Health, Örebro University, Örebro, Sweden (Thunberg); the Center for Experimental and Biomedical Imaging in Örebro, Faculty of Medicine and Health, Örebro University, Örebro, Sweden (Thunberg); and the Department of Psychiatry, Faculty of Medicine and Health, Örebro University, Örebro, Sweden (Msghina).
J Paul HamiltonFrom the Department of Clinical Neuroscience, Karolinska Institute, Stockholm, Sweden (Sklivanioti Greenfield, Msghina); the Department of Clinical Science, Intervention, and Technology, Karolinska Institute, Stockholm, Sweden (Wang); Medical Radiation Physics and Nuclear Medicine, Karolinska University Hospital, Stockholm, Sweden (Wang); the Department of Biological and Medical Psychology, University of Bergen, Norway (Hamilton); the Department for Radiology and Medical Physics, Faculty of Medicine and Health, Örebro University, Örebro, Sweden (Thunberg); the Center for Experimental and Biomedical Imaging in Örebro, Faculty of Medicine and Health, Örebro University, Örebro, Sweden (Thunberg); and the Department of Psychiatry, Faculty of Medicine and Health, Örebro University, Örebro, Sweden (Msghina).
Per ThunbergFrom the Department of Clinical Neuroscience, Karolinska Institute, Stockholm, Sweden (Sklivanioti Greenfield, Msghina); the Department of Clinical Science, Intervention, and Technology, Karolinska Institute, Stockholm, Sweden (Wang); Medical Radiation Physics and Nuclear Medicine, Karolinska University Hospital, Stockholm, Sweden (Wang); the Department of Biological and Medical Psychology, University of Bergen, Norway (Hamilton); the Department for Radiology and Medical Physics, Faculty of Medicine and Health, Örebro University, Örebro, Sweden (Thunberg); the Center for Experimental and Biomedical Imaging in Örebro, Faculty of Medicine and Health, Örebro University, Örebro, Sweden (Thunberg); and the Department of Psychiatry, Faculty of Medicine and Health, Örebro University, Örebro, Sweden (Msghina).
Mussie MsghinaFrom the Department of Clinical Neuroscience, Karolinska Institute, Stockholm, Sweden (Sklivanioti Greenfield, Msghina); the Department of Clinical Science, Intervention, and Technology, Karolinska Institute, Stockholm, Sweden (Wang); Medical Radiation Physics and Nuclear Medicine, Karolinska University Hospital, Stockholm, Sweden (Wang); the Department of Biological and Medical Psychology, University of Bergen, Norway (Hamilton); the Department for Radiology and Medical Physics, Faculty of Medicine and Health, Örebro University, Örebro, Sweden (Thunberg); the Center for Experimental and Biomedical Imaging in Örebro, Faculty of Medicine and Health, Örebro University, Örebro, Sweden (Thunberg); and the Department of Psychiatry, Faculty of Medicine and Health, Örebro University, Örebro, Sweden (Msghina) mussie.msghina@oru.se.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundEmotional dysregulation affects up to two-thirds of adult patients with attention-deficit/hyperactivity disorder (ADHD) and is increasingly seen as a core ADHD symptom that is clinically associated with greater functional impairment and psychiatric comorbidity. We sought to investigate emotional dysregulation in ADHD and explored its neural underpinnings.

methodsWe studied emotion induction and regulation in a clinical cohort of adult patients with ADHD before and after a stimulant challenge. We compared patients with age- and gender-matched healthy controls using behavioural, structural, and functional measures. We hypothesized that patients would demonstrate aberrant emotion processing compared with healthy controls, and sought to find whether this could be normalized by stimulant medication.

resultsBehaviourally, the ADHD group showed reduced emotion induction and regulation capacity. Brain imaging revealed abberant activation and deactivation patterns during emotion regulation, lower grey-matter volume in limbic and paralimbic areas, and greater grey-matter volume in visual and cerebellar areas, compared with healthy controls. The behavioural and functional deficits seen in emotion induction and regulation in the ADHD group were not normalized by stimulant medication.

conclusionPatients with ADHD may have impaired emotion induction and emotion regulation capacity, but these deficits are not reversed by stimulant medication. These results have important clinical implications when assessing which aspects of emotional dysregulation are relevant for patients and if and how traditional ADHD pharmacotherapy affects emotion induction and emotion regulation.

Indexed as

Attention Deficit Disorder with HyperactivityBrainCentral Nervous System StimulantsMagnetic Resonance ImagingAdultAffective SymptomsCase-Control StudiesEmotional RegulationEmotionsFemaleGray MatterHumansMaleMiddle AgedYoung AdultCentral Nervous System Stimulants

Identifiers

PMID39122408
PMCPMC11318975

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.