Evidence map›Paper›PMID 39122254›Full record

ArticleJournal of neurointerventional surgery2025

Neck apposition is a key factor for aneurysm occlusion after Woven EndoBridge device embolization.

Jonathan Cortese, Julia Juhasz, Fernanda Rodriguez-Erazú, Sherief Ghozy, Esref Alperen Bayraktar, Cristian Mihalea, Armin Zarrintan, Yasuhito Ueki, Jildaz Caroff, David F Kallmes and 2 more

Abstract read
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Article in Journal of neurointerventional surgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

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2citing papers in PubMed
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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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2 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

12 authors.

Jonathan CorteseDepartment of Radiology, Mayo Clinic, Rochester, MN, USA cortese.jonathan@mayo.edu.ORCID http://orcid.org/0000-0002-1616-9113
Julia JuhaszNEURI Vascular Center, Bicetre Hospital Interventional Neuroradiology, Le Kremlin-Bicetre, France.
Fernanda Rodriguez-ErazúNEURI Vascular Center, Bicetre Hospital Interventional Neuroradiology, Le Kremlin-Bicetre, France.
Sherief GhozyDepartment of Radiology, Mayo Clinic, Rochester, MN, USA.ORCID http://orcid.org/0000-0001-5629-3023
Esref Alperen BayraktarDepartment of Radiology, Mayo Clinic, Rochester, MN, USA.ORCID http://orcid.org/0000-0002-8245-2689
Cristian MihaleaNEURI Vascular Center, Bicetre Hospital Interventional Neuroradiology, Le Kremlin-Bicetre, France.
Armin ZarrintanDepartment of Radiology, Mayo Clinic, Rochester, MN, USA.ORCID http://orcid.org/0000-0002-1217-648X
Yasuhito UekiDepartment of Radiology, Mayo Clinic, Rochester, MN, USA.
Jildaz CaroffNEURI Vascular Center, Bicetre Hospital Interventional Neuroradiology, Le Kremlin-Bicetre, France.ORCID http://orcid.org/0000-0002-0029-1835
David F KallmesDepartment of Radiology, Mayo Clinic, Rochester, MN, USA.
Laurent SpelleNEURI Vascular Center, Bicetre Hospital Interventional Neuroradiology, Le Kremlin-Bicetre, France.ORCID http://orcid.org/0000-0002-6748-8528
Ramanathan KadirvelDepartment of Neurologic Surgery, Mayo Clinic Minnesota, Rochester, Minnesota, USA.ORCID http://orcid.org/0000-0002-6786-9953

Funding

Computational and Biological Approach to Flow DiversionR01NS076491 · NINDS · MAYO CLINIC ROCHESTER · PI Juan R Cebral, DAVID F KALLMES · 2011 to 2026
$7.4M
NINDS NIH HHS R01 NS076491
6 · The paper itself

Abstract

backgroundSealing of the aneurysm neck with a Woven EndoBridge (WEB) device is recommended for disrupting the blood flow inside the aneurysm. This study investigates the relationship between WEB neck apposition and aneurysm occlusion rates.

methodsAneurysms treated with a WEB from March 2017 to May 2022 at a single center were included. WEB neck apposition (poor/good) and WEB protrusion (yes/no) were evaluated on post-detachment high resolution cone beam CT images. Angiographic occlusion was assessed with the Bicêtre Occlusion Scale score (BOSS). Univariate and multivariable analysis tested the association between neck apposition and occlusion rates.

resultsThe study included 159 aneurysms in 141 patients (mean age 55.8±11.2 years; 64.2% women). Good neck apposition and protrusion were noted in 123 (77.4%) and 30 (18.9%) cases, respectively. Inter-rater agreements were good for neck apposition (κ=0.75) and protrusion (κ=0.78). Complete and adequate occlusion was achieved in 104 (65%) and 130 (82%) cases, respectively (median follow-up 18 months). Good neck apposition was a strong independent predictor for both adequate (adjusted OR (aOR)=5.9, 95% CI 2.4 to 14.9; P<0.001) and complete occlusion (aOR=7.1, 95% CI 3.0 to 18.1; P<0.001). Protrusion was more frequent in the adequate occlusion group versus the aneurysm recurrence group without reaching statistical significance (P=0.06), but was associated with more thromboembolic complications (9/30 (30%) vs 12/129 (9%); P<0.01). WEB shape modification was significantly greater in poor apposition cases (P=0.03).

conclusionsAchieving good neck apposition of the WEB strongly predicts aneurysm occlusion during follow-up. WEB protrusion should be minimized due to the increase in thromboembolic risk with limited impact on aneurysm occlusion.

Indexed as

Embolization, TherapeuticIntracranial AneurysmAdultAgedFemaleFollow-Up StudiesHumansMaleMiddle AgedRetrospective StudiesTreatment OutcomeAneurysmDevice

Identifiers

PMID39122254
PMCPMC12301996

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.