Evidence map›Paper›PMID 39122243›Full record

ArticleInternational journal of immunopathology and pharmacology

HERV-K np9 and HERV-R env: Two endogenous retrovirus products with potential Pathogenic roles in pediatric acute lymphoblastic leukemia.

Noha Gaber, Ahmed Samir Abdelhafiz, Nivin Abdel-Azim, Azza Shibl, Lamiaa Fadel, Zeinab Korany Hassan, Eman Hassan Ahmed

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Article in International journal of immunopathology and pharmacology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

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5 · Who and what money

Authors and funding

7 authors.

Noha GaberClinical Pathology Department, South Egypt Cancer Institute, Assiut University, Assiut, Egypt.
Ahmed Samir AbdelhafizClinical Pathology Department, National Cancer Institute, Cairo University, Cairo, Egypt.ORCID 0000-0003-4564-8073
Nivin Abdel-AzimCancer Biology Department, South Egypt Cancer Institute, Assiut University, Assiut, Egypt.
Azza ShiblPediatric Oncology Department, South Egypt Cancer Institute, Assiut University, Assiut, Egypt.
Lamiaa FadelCancer Biology Department, South Egypt Cancer Institute, Assiut University, Assiut, Egypt.
Zeinab Korany HassanVirology and Immunology Unit, Cancer Biology Department, National Cancer Institute, Cairo University, Cairo, Egypt.
Eman Hassan AhmedClinical Pathology Department, South Egypt Cancer Institute, Assiut University, Assiut, Egypt.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesHuman endogenous retroviruses (HERVs) are integral components of the human genome, and their reactivation has been implicated in the pathogenesis of some malignancies. External viral co-infections are suspected to play a role in HERV transactivation. This study aimed to investigate the expression of HERV-K np9 elements and HERV-R env gene in pediatric acute lymphoblastic leukemia (ALL) patients. Additionally, we explored potential correlations between HERV expression and common viral infections prevalent in this group of patients.

methodsBlood samples were collected from 43 pediatric ALL patients and 48 age- and sex-matched healthy controls. Quantitative real-time PCR (qRT-PCR) was used to assess the expression of HERV-K np9 and HERV-R env, along with herpes simplex virus (HSV), parvovirus B19, and polyomavirus BK.

resultsHERV-K np9 and HERV-R env showed significantly higher expression in the peripheral blood of ALL patients compared to healthy controls (

conclusionThe overexpression of HERV-K np9 and HERV-R env in pediatric ALL patients suggest their potential role in leukemogenesis. Our findings also suggest a possible link between HSV infection and HERV reactivation in this population. Future investigations are needed to understand the precise roles of these genes and viral infections in the development of ALL.

Indexed as

Endogenous RetrovirusesPrecursor Cell Lymphoblastic Leukemia-LymphomaAdolescentCase-Control StudiesChildChild, PreschoolFemaleGene Products, envHumansMaleGene Products, envacute lymphoblastic leukemia-lymphomaendogenous retrovirusesherpes simplexHERV-K np9human

Identifiers

PMID39122243
PMCPMC11316263

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.