Evidence map›Paper›PMID 39122134›Full record

ArticleAlcohol (Fayetteville, N.Y.)2024

The effects of moderate prenatal alcohol exposure on performance in hippocampal-sensitive spatial memory and anxiety tasks by adult male and female rat offspring.

Gabriela Acosta, Kehiry Trejo Rico, John T Madden, Ariyana LaCour, Enhui Wang, Lilliana M Sanchez, Suzy Davies, Carlos Maestas-Olguin, Kayla B Cox, Nicole C Reyna and 4 more

Abstract read
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In one paragraph

Article in Alcohol (Fayetteville, N.Y.), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Assessment of GABANeuroscience letters · 2026
    Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Gabriela AcostaDepartment of Psychology, University of New Mexico, Albuquerque, NM, USA.
Kehiry Trejo RicoDepartment of Psychology, University of New Mexico, Albuquerque, NM, USA.
John T MaddenDepartment of Psychology, University of New Mexico, Albuquerque, NM, USA.
Ariyana LaCourDepartment of Psychology, University of New Mexico, Albuquerque, NM, USA.
Enhui WangDepartment of Psychology, University of New Mexico, Albuquerque, NM, USA.
Lilliana M SanchezDepartment of Psychology, University of New Mexico, Albuquerque, NM, USA.
Suzy DaviesDepartment of Neurosciences, University of New Mexico, Albuquerque, NM, USA.
Carlos Maestas-OlguinDepartment of Psychology, University of New Mexico, Albuquerque, NM, USA.
Kayla B CoxDepartment of Psychology, University of New Mexico, Albuquerque, NM, USA.
Nicole C ReynaDepartment of Psychology, University of New Mexico, Albuquerque, NM, USA.
Jeremy HogeveenDepartment of Psychology, University of New Mexico, Albuquerque, NM, USA.
Daniel D SavageDepartment of Psychology, University of New Mexico, Albuquerque, NM, USA; Department of Neurosciences, University of New Mexico, Albuquerque, NM, USA.
Nathan S PentkowskiDepartment of Psychology, University of New Mexico, Albuquerque, NM, USA.
Benjamin J ClarkDepartment of Psychology, University of New Mexico, Albuquerque, NM, USA; Department of Neurosciences, University of New Mexico, Albuquerque, NM, USA. Electronic address: bnjclark@unm.edu.

Funding

Understanding neurophysiological deficits in response inhibition in children with FASDP50AA022534 · NIAAA · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI Carlos Fernando Valenzuela · 2014 to 2026
$21.5M
Alcohol Research Training in NeurosciencesT32AA014127 · NIAAA · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI Jonathan L Brigman · 2003 to 2026
$3.3M
Neural Basis of Spatial Memory Deficits After Prenatal Alcohol ExposureR01AA029700 · NIAAA · UNIVERSITY OF NEW MEXICO · PI Benjamin J Clark · 2022 to 2026
$1.6M
Rhythms of Hippocampal Function and Memory Deficits After Moderate Prenatal Alcohol ExposureF31AA030711 · NIAAA · UNIVERSITY OF NEW MEXICO · PI SANCHEZ, LILLIANA MAY · 2022 to 2024
$112k
NIAAA NIH HHS F31 AA030711NIAAA NIH HHS P50 AA022534NIAAA NIH HHS R01 AA029700NIAAA NIH HHS T32 AA014127
6 · The paper itself

Abstract

Moderate prenatal alcohol exposure (mPAE) results in structural alterations to the hippocampus. Previous studies have reported impairments in hippocampal-sensitive tasks, but have not compared performance between male and female animals. In the present study, performance in hippocampal-sensitive spatial memory and anxiety behavior tests were compared across adult male and female saccharin (SACC) control mPAE Long-Evans rat offspring. Two tests of spatial memory were conducted that were aimed at assessing memory for recently acquired spatial information: A delayed spatial alternation task using an M-shaped maze and a delayed match-to-place task in the Morris water task. In both tasks, rats in SACC and mPAE groups showed similar learning and retention of a spatial location even after a 2-h interval between encoding and retention. A separate group of adult male and female SACC and mPAE rat offspring were tested for anxiety-like behaviors in the elevated plus-maze paradigm. In this test, both male and female mPAE rats exhibited a significantly greater amount of time and a greater number of head dips in the open arms, while locomotion and open arm entries did not differ between groups. The results suggest that mPAE produces a reduction in anxiety-like behaviors in both male and female rats in the elevated plus-maze.

Indexed as

EthanolHippocampusMaze LearningMemoryAnimalsAnxietyFemaleMalePregnancyPrenatal Exposure Delayed EffectsRatsRats, Long-EvansEthanolanxietyelevated plus-mazefetal ethanolhippocampusspatial alternationspatial memory

Identifiers

PMID39122134
PMCPMC11637952

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.