Evidence map›Paper›PMID 39121650›Full record

ArticleStem cell research2024

Characterization of an induced pluripotent stem cell line (NCHi013-A) from a 5-year-old male with pulmonary atresia with intact ventricular septum and a biventricular repair.

Meghan Hanley, Matthew Alonzo, Shiqiao Ye, Yang Yu, Javier Contreras, Jade Hayden, Vidu Garg, Ming-Tao Zhao

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Stem cell research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Meghan HanleyCenter for Cardiovascular Research, Abigail Wexner Research Institute, Nationwide Children's Hospital, Columbus, OH 43215, USA; The Heart Center, Nationwide Children's Hospital, Columbus, OH 43215, USA.
Matthew AlonzoCenter for Cardiovascular Research, Abigail Wexner Research Institute, Nationwide Children's Hospital, Columbus, OH 43215, USA; The Heart Center, Nationwide Children's Hospital, Columbus, OH 43215, USA.
Shiqiao YeCenter for Cardiovascular Research, Abigail Wexner Research Institute, Nationwide Children's Hospital, Columbus, OH 43215, USA; The Heart Center, Nationwide Children's Hospital, Columbus, OH 43215, USA.
Yang YuCenter for Cardiovascular Research, Abigail Wexner Research Institute, Nationwide Children's Hospital, Columbus, OH 43215, USA; The Heart Center, Nationwide Children's Hospital, Columbus, OH 43215, USA.
Javier ContrerasCenter for Cardiovascular Research, Abigail Wexner Research Institute, Nationwide Children's Hospital, Columbus, OH 43215, USA; The Heart Center, Nationwide Children's Hospital, Columbus, OH 43215, USA.
Jade HaydenCenter for Cardiovascular Research, Abigail Wexner Research Institute, Nationwide Children's Hospital, Columbus, OH 43215, USA; The Heart Center, Nationwide Children's Hospital, Columbus, OH 43215, USA.
Vidu GargCenter for Cardiovascular Research, Abigail Wexner Research Institute, Nationwide Children's Hospital, Columbus, OH 43215, USA; The Heart Center, Nationwide Children's Hospital, Columbus, OH 43215, USA; Department of Pediatrics, The Ohio State University College of Medicine, Columbus, OH 43210, USA; Dorothy M. Davis Heart and Lung Research Institute, The Ohio State University Wexner Medical Center, Columbus, OH 43210, USA.
Ming-Tao ZhaoCenter for Cardiovascular Research, Abigail Wexner Research Institute, Nationwide Children's Hospital, Columbus, OH 43215, USA; The Heart Center, Nationwide Children's Hospital, Columbus, OH 43215, USA; Department of Pediatrics, The Ohio State University College of Medicine, Columbus, OH 43210, USA; Dorothy M. Davis Heart and Lung Research Institute, The Ohio State University Wexner Medical Center, Columbus, OH 43210, USA. Electronic address: mingtao.zhao@nationwidechildrens.org.

Funding

An integrated human stem cell model for elucidating NOTCH signaling in myocardial-endocardial interactions in cardiac development and diseaseR01HL155282 · NHLBI · RESEARCH INST NATIONWIDE CHILDREN'S HOSP · PI Mingtao Zhao · 2021 to 2026
$3.2M
A Dynamic and Three-Dimensional Human Model of Hypoplastic Left Heart Syndrome to Probe Compromised Cardiomyocyte ProliferationF32HL170581 · NHLBI · RESEARCH INST NATIONWIDE CHILDREN'S HOSP · PI Matthew Alonzo · 2024 to 2026
$241k
A HUMAN IPSC-BASED ORGANOID PLATFORM FOR STUDYING MATERNAL HYPERGLYCEMIA-INDUCED CONGENITAL HEART DEFECTSF31HD113330 · NICHD · RESEARCH INST NATIONWIDE CHILDREN'S HOSP · PI Javier Contreras · 2023 to 2026
$128k
NHLBI NIH HHS F32 HL170581NHLBI NIH HHS R01 HL155282NICHD NIH HHS F31 HD113330
6 · The paper itself

Abstract

Pulmonary atresia with intact ventricular septum (PA/IVS) is a rare congenital heart defect that causes a significant decrease of blood outflow from the heart and is fatal if left untreated. iPSC line NCHi013-A was produced from peripheral blood mononuclear cells from a male child with PA/IVS using Sendai virus reprogramming. NCHi013-A displayed normal stem cell morphology, expressed markers for pluripotency, and presented ability to differentiate into cells of endoderm, ectoderm, and mesoderm lineages. The iPSC line also maintained normal karyotype, was validated for cell identity, and tested negative for transgenes and mycoplasma contamination.

Indexed as

Induced Pluripotent Stem CellsPulmonary AtresiaCell DifferentiationCell LineChild, PreschoolHeart Defects, CongenitalHumansMale

Identifiers

PMID39121650
PMCPMC11404849

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.