ArticleAmerican journal of clinical pathology2025
Primary intestinal T-cell and natural killer-cell lymphomas: Clinicopathologic and prognostic features of 79 cases in South China.
Article in American journal of clinical pathology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- The surgery for the patients with intestinal non‑Hodgkin lymphomas: a nationwide study.Annals of medicine · 2026Article
- Case Report: Targeting the Achilles' heel of monomorphic epitheliotropic intestinal T-cell lymphoma.Frontiers in oncology · 2026Article
- Small intestinal NK/T-cell lymphoma with malignant peritoneal effusion as the first symptom: a case report and literature review.Frontiers in medicine · 2025Article
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7 authors.
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Abstract
objectivesPrimary intestinal T-cell and natural killer-cell lymphomas (PITNKLs) are aggressive and make pathologic diagnoses in biopsy specimens challenging. We analyzed different subtypes' clinicopathologic features and treatment outcomes.
methodsSeventy-nine PITNKL cases were characterized by clinical, morphologic, and immunohistochemical features.
resultsAmong 79 cases of PITNKLs from 2008 to 2017 in our institution, 40 (50.63%) were extranodal NK/T-cell lymphoma, nasal type (ENKTL); 32 (40.51%) monomorphic epitheliotropic intestinal T-cell lymphoma (MEITL); 6 (7.59%) intestinal T-cell lymphoma, not otherwise specified; and 1 (1.27%) indolent T-cell lymphoma of the gastrointestinal tract. Small intestine (n = 47) was the most common site. Monomorphic epitheliotropic intestinal T-cell lymphoma showed distinctive clinicopathologic features from other subtypes with high expression (96.88%) of spleen tyrosine kinase (SYK) and PD-L1 (87.5%) and the poorest prognosis (P < .001). CD30 was highly expressed in ENKTL (9/17, 57.94%) and irrelevant to prognosis (P > .05).
conclusionsCases of PITNKL are biologically heterogeneous; most have a dismal prognosis. SYK and PD-L1 expression might be a significant marker for MEITL and helps differential diagnosis.
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