Evidence map›Paper›PMID 39120842›Full record

ArticleAnnals of surgical oncology2024

Dynamic Anthropometrics in Pancreatic Cancer: Associations Between Body Composition Changes During Neoadjuvant Therapy and Survival Outcomes After Resection.

Elliott J Yee, Robert J Torphy, Emily K Myers, Cheryl Meguid, Oskar Franklin, Toshitaka Sugawara, Salvador Rodriguez Franco, Toshimasa J Clark, Benedetto Mungo, Steven A Ahrendt and 3 more

Abstract read
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In one paragraph

Article in Annals of surgical oncology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Observational
  2. When adipose meets inflammation: a novel adiposity-inflammation signature predicts prognosis and chemotherapy benefit in locally advanced gastric cancer.Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Elliott J YeeDivision of Surgical Oncology, Department of Surgery, University of Colorado School of Medicine, Aurora, CO, USA.
Robert J TorphyDivision of Surgical Oncology, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York City, NY, USA.
Emily K MyersDivision of Surgical Oncology, Department of Surgery, University of Colorado School of Medicine, Aurora, CO, USA.
Cheryl MeguidDivision of Surgical Oncology, Department of Surgery, University of Colorado School of Medicine, Aurora, CO, USA.
Oskar FranklinDivision of Surgical Oncology, Department of Surgery, University of Colorado School of Medicine, Aurora, CO, USA.
Toshitaka SugawaraDepartment of Hepatobiliary and Pancreatic Surgery, Graduate School of Medicine, Tokyo Medical and Dental University, Tokyo, Japan.
Salvador Rodriguez FrancoDivision of Surgical Oncology, Department of Surgery, University of Colorado School of Medicine, Aurora, CO, USA.
Toshimasa J ClarkDivision of Abdominal Imaging, Department of Radiology, University of Colorado School of Medicine, Aurora, CO, USA.
Benedetto MungoDivision of Surgical Oncology, Department of Surgery, University of Colorado School of Medicine, Aurora, CO, USA.
Steven A AhrendtDivision of Surgical Oncology, Department of Surgery, University of Colorado School of Medicine, Aurora, CO, USA.
Richard D SchulickDivision of Surgical Oncology, Department of Surgery, University of Colorado School of Medicine, Aurora, CO, USA.
Marco Del ChiaroDivision of Surgical Oncology, Department of Surgery, University of Colorado School of Medicine, Aurora, CO, USA.
Martin M McCarterDivision of Surgical Oncology, Department of Surgery, University of Colorado School of Medicine, Aurora, CO, USA. Martin.mccarter@cunanschutz.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAssessment of individual tumor biology and response to systemic therapy in pancreatic ductal adenocarcinoma (PDAC) remains a clinical challenge. The significance of anthropometric (body composition) changes during chemotherapy as a surrogate for tumor biology in the setting of localized PDAC is unknown.

methodsA retrospective, single-institution analysis of patients with PDAC who received neoadjuvant therapy (NAT) and pancreatectomy from 2017 to 2021 was performed. Radiologic anthropometric analysis used artificial intelligence-driven software to segment and compute total and sub-compartment muscle area, adipose tissue area, and attenuation values at the level of the L3 vertebra. Kaplan-Meier survival estimates, log-rank tests, and multivariable Cox regression models were used in survival analyses.

resultsThe inclusion criteria were met by 138 patients. Although decreases in muscle and adipose tissue areas during NAT were predominant, a subset of patients experienced an increase in these compartments. Increases in muscle greater than 5% (hazard ratio [HR], 0.352; 95% confidence interval [CI] 0.135-0.918; p = 0.033) and increases in adipose tissue greater than 15% (HR, 0.375; 95% CI 0.144-0.978; p = 0.045), were significantly associated with improved survival, whereas loss of visceral fat greater than 15% was detrimental (HR 1.853; CI 1.099-3.124; p = 0.021). No significant associations with single time-point anthropometrics were observed. Gains in total muscle and adipose mass were associated with improved pathologic response to systemic therapy and less advanced pathologic tumor stage.

conclusionsDynamic anthropometric analysis during NAT for PDAC is a stronger prognostic indicator than measurements taken at a single point in time. Repeated anthropometric analysis during preoperative chemotherapy may serve as a biomarker for individual tumor biology and response to therapy.

Indexed as

Body CompositionCarcinoma, Pancreatic DuctalNeoadjuvant TherapyPancreatectomyPancreatic NeoplasmsAdipose TissueAgedAnthropometryAntineoplastic Combined Chemotherapy ProtocolsFemaleFollow-Up StudiesHumansMaleMiddle AgedPrognosisRetrospective StudiesAnthropometricsPancreatic cancerPathologic responseSurvival

Identifiers

PMID39120842

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.