ReviewCancer metastasis reviews2024
Advances in the molecular biology of the solitary fibrous tumor and potential impact on clinical applications.
Review in Cancer metastasis reviews, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed.
- Intracranial solitary fibrous tumor with multiloculated cystic change: A case report.Radiology case reports · 2026Article
- Construction and Characterization of Paired Patient-Derived Cell Models for Solitary Fibrous Tumors (SFTs).Cancers · 2026Article
- Recurrent Pleural Solitary Fibrous Tumor: A Case Report and Brief Literature Review.Reports (MDPI) · 2026Article
- Spinal solitary fibrous tumor metastatic to the fourth ventricle: illustrative case.Journal of neurosurgery. Case lessons · 2026Article
- Depicting Characteristic Staghorn Vessels in Solitary Fibrous Tumor of the Liver With Contrast-Enhanced Ultrasound and Ultrasound Localized Microscopy: A Case Report.The American journal of case reports · 2026Article
- Primary Hepatic Solitary Fibrous Tumour: A Rare Mesenchymal Entity with Distinct Histopathologic and Molecular Features.Diagnostics (Basel, Switzerland) · 2026Article
- Pancreatic Solitary Fibrous Tumor: A Common Tumor Occurring in a Rare Location.The American journal of case reports · 2026Article
- A hepatic solitary fibrous tumor with giant cells and a review of the literature.Discover oncology · 2026Article
- Clinicopathological characteristics and outcomes of 42 cases of ocular adnexal sarcoma.International ophthalmology · 2026Article
- Hippo signalling pathway mediates oncogenic properties of NAB2::STAT6 in solitary fibrous tumour.Cellular oncology (Dordrecht, Netherlands) · 2026Article
- Primary orbital solitary fibrous tumor with an 18-year course of five recurrences and extensive sinonasal metastasis following eyeball enucleation: a case report.Frontiers in medicine · 2026Article
- Case Report: Intramedullary solitary fibrous tumor at the C7-T1 level diagnosed by STAT6 and treated with maximal safe resection.Frontiers in surgery · 2026Article
- Case Report: Giant communicating solitary fibrous tumor of the temporal skull base and infratemporal fossa.Frontiers in surgery · 2026Article
- Robot-assisted laparoscopic resection of giant pelvic solitary fibrous tumor: a case report with literature review.Frontiers in oncology · 2026Article
- Solitary fibrous tumor: an updated review.Journal of pathology and translational medicine · 2026Article
- Solitary fibrous tumor of the sublingual gland: a case report.Frontiers in oral health · 2026Article
- Solitary fibrous tumors from A to Z: a pictorial review with radiologic-pathologic correlation.Insights into imaging · 2025Article
- Solitary fibrous tumor in the pineal region: A series of 5 cases and literature review.Journal of neuropathology and experimental neurology · 2025Review
- Solitary Fibrous Tumor.Cancers · 2024Article
- Hemangiopericytoma following allogeneic hematopoietic stem cell transplantation in a patient with primary plasma cell leukemia: the first case report and literature review.Frontiers in oncology · 2024Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Solitary fibrous tumor (SFT) is a rare fibroblastic mesenchymal neoplasm. The current classification has merged SFT and hemangiopericytoma (HPC) into the same tumor entity, while the risk stratification models have been developed to compensate for clinical prediction. Typically, slow-growing and asymptomatic, SFT can occur in various anatomical sites, most commonly in the pleura. Histologically, SFT consists of spindle to oval cells with minimal patterned growth, surrounded by stromal collagen and unique vascular patterns. Molecularly, SFT is defined by the fusion of NGFI-A-binding protein 2 (NAB2) and signal transducer and activator of transcription 6 (STAT6) genes as NAB2-STAT6. This fusion transforms NAB2 into a transcriptional activator, activating early growth response 1 (EGR1) and contributing to SFT pathogenesis and development. There are several fusion variants of NAB2-STAT6 in tumor tissues, with the most frequent ones being NAB2ex4-STAT6ex2 and NAB2ex6-STAT6ex16/ex17. Diagnostic methods play a crucial role in SFT clinical practice and basic research, including RT-PCR, next-generation sequencing (NGS), FISH, immunohistochemistry (IHC), and Western blot analysis, each with distinct capabilities and limitations. Traditional treatment strategies of SFT encompass surgical resection, radiation therapy, and chemotherapy, while emerging management regimes include antiangiogenic agents, immunotherapy, RNA-targeting technologies, and potential targeted drugs. This review provides an update on SFT's clinical and molecular aspects, diagnostic methods, and potential therapies.
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