ReviewArchives of gynecology and obstetrics2024
Advanced maternal age (AMA) and pregnancy: a feasible but problematic event.
Review in Archives of gynecology and obstetrics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed.
- Maternal age as a driver of genome instability: mechanisms linking aneuploidy, mutagenesis and mitochondrial dysfunction.Archives of toxicology · 2026Review
- A Human Rights-Based and Relational Justice Approach to Assisted Reproduction in Spain.Bioethics · 2026Article
- Recipient age and reproductive outcomes in donor oocyte cycles: exploring the potential contribution of uterine aging.Journal of assisted reproduction and genetics · 2026Article
- Severe maternal morbidity in patients of advanced maternal age with and without metabolic syndrome.Archives of gynecology and obstetrics · 2026Article
- Influence of advanced maternal age (≥35 years) on maternal and neonatal outcomes in vaginally intended breech deliveries at term-A FRABAT study.International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics · 2026Article
- Comparison status and factors of pregnancy stress among pregnant women with second child between advanced maternal age and reproductive age: a cross-sectional study.BMC pregnancy and childbirth · 2026Article
- Dose-response relationship between early pregnancy blood pressure and gestational diabetes mellitus based on propensity score matching: a retrospective study.BMC pregnancy and childbirth · 2026Article
- Association between demographic-socioeconomic factors and grouped trajectory patterns of peer support needs in parents of preterm infants: a longitudinal exploration.BMC pediatrics · 2026Article
- Impact of Different Maternal Age Subgroups on Pregnancy Adverse Outcomes in China: A Multicenter Cohort Study.Health science reports · 2026Article
- Venous Thromboembolism Associated with Uterine Fibroids: A Review of Reported Cases.Journal of clinical medicine · 2026Review
- Physical Activity and Its Predictors Among Women of Advanced Maternal Age in the First Trimester: A Cross-Sectional Study.International journal of women's health · 2026Article
- Advanced maternal age and assisted reproductive technologies: outcomes, genomics, and real-world evidence.Frontiers in reproductive health · 2026Review
- A prospective descriptive cohort study of women aged ≥40 years conceiving through IVF at a tertiary care center.Frontiers in reproductive health · 2026Article
- Real-world evaluation of Chinese National Maternal and Newborn Safety Action Plan for reducing neonatal mortality among pregnant women with conditions: a retrospective, matched, population-based cohort study.BMJ public health · 2026Article
- Diagnostic Utility of Extracellular Levels of Serum Amyloid P and Proteoglycan 4: A Case-Control Study in Gestational Diabetes Mellitus.International journal of general medicine · 2026Article
- Maternal Mortality Transition and Subnational Inequities in China, 1990-2023: Comparative Analysis of GBD 2023 and National Surveillance Data.International journal of women's health · 2026Article
- Genomic risk profiling in advanced maternal age: a Tamil Nadu prenatal study.Frontiers in medicine · 2026Article
- Monocytes at the crossroads of inflammation and labor: biomarker potential in prolonged deliveries - a narrative review.Annals of medicine and surgery (2012) · 2025Article
- Fetomaternal Outcome Among Antenatal Attendees With Advanced Maternal Age: A Cohort Study.Cureus · 2025Article
- Postponed childbearing: a cross-sectional study of differences between subjective and objective factors.Annals of medicine · 2025Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This narrative review aimed to summarize all adverse outcomes of pregnancy in advanced maternal age (AMA) to assess the age of the mother as a potentially crucial risk factor. AMA refers to women older than 35 years. While expectations and the role of women in society have undergone significant changes today, the biology of aging remains unchanged. Various pathologic changes occur in the human body with age, including chronic noncommunicable diseases, as well as notable changes in reproductive organs, that significantly affect fertility. Despite substantial advancements in technology and medicine, pregnancy in AMA remains a formidable challenge. Although there are some advantages to postponing childbirth, they primarily relate to maternal maturity and economic stability. However, regrettably, there are also many adverse aspects of pregnancy at advanced ages. These include complications affecting both the mother and the fetus. Pregnants in AMA were more prone to suffer from gestational diabetes mellitus, preeclampsia, and eclampsia during pregnancy compared to younger women. In addition, miscarriages and ectopic pregnancies were more prevalent. Delivery was more frequently completed via cesarean section, and postpartum complications and maternal mortality were also higher. Unfortunately, there were also complications concerning the fetus, such as chromosomal abnormalities, premature birth, low birth weight, admission to the neonatal intensive care unit, and stillbirth.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.