Evidence map›Paper›PMID 39120548›Full record

ArticleJournal of cellular and molecular medicine2024

Exploring the relationship between anal fistula and colorectal cancer based on Mendelian randomization and bioinformatics.

Yicheng Liu, Wenjun Zhao, Weiye Hu, Jin Xu, Haiyan Zhang, Ting Huang, Chuang Wu, Jiajia Yang, Wenjing Mao, Xiaobing Yao and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of cellular and molecular medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Yicheng LiuDepartment of Anorectal Surgery, Shanghai Baoshan Hospital of Intergrated Traditonal Chinese and Western Medicine, Shanghai, China.ORCID 0009-0008-7641-1451
Wenjun ZhaoDepartment of Anorectal Surgery, Shanghai Baoshan Hospital of Intergrated Traditonal Chinese and Western Medicine, Shanghai, China.
Weiye HuDepartment of Liver, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Jin XuDepartment of Anorectal Surgery, Shanghai Baoshan Hospital of Intergrated Traditonal Chinese and Western Medicine, Shanghai, China.
Haiyan ZhangDepartment of Anorectal Surgery, Shanghai Baoshan Hospital of Intergrated Traditonal Chinese and Western Medicine, Shanghai, China.
Ting HuangDepartment of Anorectal Surgery, Shanghai Baoshan Hospital of Intergrated Traditonal Chinese and Western Medicine, Shanghai, China.
Chuang WuDepartment of Anorectal Surgery, Shanghai Baoshan Hospital of Intergrated Traditonal Chinese and Western Medicine, Shanghai, China.
Jiajia YangDepartment of Anorectal Surgery, Shanghai Baoshan Hospital of Intergrated Traditonal Chinese and Western Medicine, Shanghai, China.
Wenjing MaoDepartment of Anorectal Surgery, Shanghai Baoshan Hospital of Intergrated Traditonal Chinese and Western Medicine, Shanghai, China.
Xiaobing YaoDepartment of Gastrointestinal Surgery, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Yafeng LuDepartment of Anorectal Surgery, Shuguang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Qingming WangDepartment of Anorectal Surgery, Shanghai Baoshan Hospital of Intergrated Traditonal Chinese and Western Medicine, Shanghai, China.

Funding

14th Five Year Plan Traditional Chinese Medicine Specialty and Traditional Chinese Medicine Emergency Capacity Improvement Project ZYTSZK182023 Shanghai Science and Technology Innovation Action Plan Medical Innovation Research Project 23Y11921800
6 · The paper itself

Abstract

The association between anal fistula patients and colorectal cancer, as well as the potential pathophysiological mechanisms, remains unclear. To explore the relationship between anal fistula and colorectal cancer and its potential mechanisms. Analysis of GEO and TCGA databases. Disease-related genes were also referenced from Coremine Medical, GeneCard and OMIM. Core hub genes were identified through protein-protein interaction analysis by intersecting differentially expressed genes from the datasets with disease data. On one hand, a prognostic model was developed using genes and its prognostic role was validated. On the other hand, the optimal diagnostic genes were selected through machine learning. Mendelian randomization (MR) analysis was conducted to explore the potential causal link between anal fistula and colorectal cancer. Thirteen core genes were identified (TMEM121B, PDGFRA, MID2, WNT10B, HOXD13, BARX1, SIX2, MMP1, SNAL1, CDKN2A, ITGB3, TIMP1, CALB2). Functional enrichment analysis revealed that the intersecting genes between anal fistula and colorectal cancer were associated with extracellular matrix components, signalling pathways, cell growth, protein modification, as well as important roles in cellular activities, tissue and organ development, and biological function maintenance. These genes were also involved in pathways related to Wnt signalling and colorectal cancer development. Prognostic analysis and immune infiltration analysis indicated a close relationship between core hub genes and the prognosis and immune infiltration in colorectal cancer. Machine learning showed that core genes played an essential role in the diagnostic differentiation of colorectal cancer. MR results suggested no causal relationship between anal fistula and colorectal cancer. This study identified shared core genes between anal fistula and colorectal cancer, involved in various pathways related to tumour development. These genes play crucial roles in prognosis and diagnosis.

Indexed as

Colorectal NeoplasmsComputational BiologyMendelian Randomization AnalysisRectal FistulaBiomarkers, TumorGene Expression ProfilingGene Expression Regulation, NeoplasticGene Regulatory NetworksGenetic Predisposition to DiseaseHumansPrognosisProtein Interaction MapsBiomarkers, Tumoranal fistulacolorectal cancercore genesmachine learningprognostic analysis

Identifiers

PMID39120548
PMCPMC11312262

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.