ArticleAmerican journal of physiology. Heart and circulatory physiology2024
Sex differences in gray matter, white matter, and regional brain perfusion in young, healthy adults.
Article in American journal of physiology. Heart and circulatory physiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07212712 (The Role of Estrogen and Testosterone in Determining Brain Blood Flow and Metabolic Regulation in Humans), which is not on this map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Role of Estrogen and Testosterone in Determining Brain Blood Flow and Metabolic Regulation in Humans
Who cites it
21 citing papers in PubMed.
- Brain and physiological responses to flavored waters with different sweeteners: a randomized crossover study in healthy young adults.The American journal of clinical nutrition · 2026Trial
- Exercise Training Reduces Cerebrovascular Impedance in Patients with Amnestic Mild Cognitive Impairment: A 1-Year Randomized Controlled Trial.Medicine and science in sports and exercise · 2026Trial
- Sex-related variability of white-matter tracts is robust to tractography methodology.Brain structure & function · 2026Article
- Female vulnerability to microvascular transport dysfunction emerges early across the Alzheimer's disease continuum.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Sex comparison of cerebrovascular reactivity to COJournal of applied physiology (Bethesda, Md. : 1985) · 2026Article
- Regional Brain Volume Variation Across Adulthood: A Cross-Sectional MRI Analysis of Age, Sex, and Hemispheric Asymmetry.Life (Basel, Switzerland) · 2026Article
- Hyperoxic cerebral vasoconstriction in healthy humans: global, lobe, and regions of interest.Journal of applied physiology (Bethesda, Md. : 1985) · 2026Article
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- Sex differences in cerebrovascular function across an aerobic exercise intervention in older adults using MRI: Results from the Brain in Motion study.Physiological reports · 2026Article
- Relationship Between Degree of Stenosis and Time-to-Peak Delay in High Grade Asymptomatic Carotid Artery Disease.Stroke · 2026Article
- A longitudinal study of quantitative pulmonary dynamic contrast enhanced MRI following COVID-19 infection.Respiratory research · 2026Article
- Brain strain: Blood flow and metabolism in environmental extremes.Experimental physiology · 2026Review
- Carotid intraplaque neovascularization increases the risk of white matter hyperintensity progression: a prospective cohort study.Frontiers in neuroscience · 2026Article
- Cerebral Blood Flow and Blood-Brain Barrier Water Exchange in Major Depressive Disorder: Evidence from Diffusion-Prepared Arterial Spin Labelling MRI.Brain sciences · 2025Article
- From Electron Imbalance to Network Collapse: Decoding the Redox Code of Ischemic Stroke for Biomarker-Guided Precision Neuroprotection.International journal of molecular sciences · 2025Review
- Transcatheter Aortic Valve Implantation and Cognitive Function: Treating the Heart, Altering the Brain?Structural heart : the journal of the Heart Team · 2025Article
- Sexual Dimorphism in Levodopa-Induced Dyskinesia Following Parkinson's Disease: Uncharted Territory.The European journal of neuroscience · 2025Review
- Regional cerebral pulsatile hemodynamics during isocapnic and poikilocapnic hyperthermia in young men.Physiological reports · 2025Article
- Sex differences in sleep apnea and Alzheimer's Disease: role of cerebrovascular dysfunction.npj women's health · 2025Review
Corrections and comments
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Authors and funding
12 authors.
Funding
Abstract
Cerebrovascular and neurological diseases exhibit sex-specific patterns in prevalence, severity, and regional specificity, some of which are associated with altered cerebral blood flow (CBF). Females often exhibit higher resting CBF, but understanding the impact of sex per se on CBF is hampered by study variability in age, comorbidities, medications, and control for menstrual cycle or hormone therapies. A majority of studies report whole brain CBF without differentiating between gray and white matter or without assessing regional CBF. Thus fundamental sex differences in regional or whole brain CBF remain unclarified. While controlling for the above confounders, we tested the hypothesis that females will exhibit higher total gray and white matter perfusion as well as regional gray matter perfusion. Adults 18-30 yr old (females = 22 and males = 26) were studied using arterial spin labeling (ASL) magnetic resonance imaging (MRI) scans followed by computational anatomy toolbox (CAT12) analysis in statistical parametric mapping (SPM12) to quantify CBF relative to brain volume. Females displayed 40% higher perfusion globally (females = 62 ± 9 and males = 45 ± 10 mL/100 g/min,
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.