Trial reportThe British journal of psychiatry : the journal of mental science2024
Childhood trauma and differential response to long-term psychoanalytic versus cognitive-behavioural therapy for chronic depression in adults.
Trial report in The British journal of psychiatry : the journal of mental science, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
9 citing papers in PubMed.
- Adverse life experiences and psychopathology trajectories in routine Cognitive Behaviour Therapy.European journal of psychotraumatology · 2026Observational
- Natural medicine‑empowered treatment of depression via restoring neurogenesis (Review).Molecular medicine reports · 2026Review
- Distinguishing Chronic and Non-Chronic Depression: A Clinical Profile and Symptom Networks Approach.Psychotherapy and psychosomatics · 2026Article
- Remote Mindfulness Training for Health Following Early Life Adversity: A Randomized Controlled Feasibility Trial.Behavior therapy · 2026Article
- Psychoanalysis in times of plurality of sciences illustrated by the LAC depression study and the MODE study.Frontiers in psychology · 2026Review
- Sustaining transformations in psychoanalysis: an interdisciplinary case study on trauma, dreams, and memory reconsolidation.Frontiers in psychology · 2026Review
- Is psychotherapy orientation important for depressive and anxiety disorder-related work disability outcomes? A prospective nationwide register study.BMC psychiatry · 2025Article
- Childhood trauma and treatment outcomes in short-term psychodynamic and cognitive behavioral therapy for adult depression.Frontiers in psychiatry · 2025Article
- Clinical conceptualisation of PTSD in psilocybin treatment: disrupting a pre-determined and over-determined maladaptive interpretive framework.Therapeutic advances in psychopharmacology · 2025Review
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
backgroundChildhood trauma is a major risk factor for chronic depression. It has been suggested that adults with chronic depression who have experienced childhood trauma may require long-term treatment owing to a breakdown of basic trust and related difficulties in developing a productive therapeutic relationship.
aimsAs empirical studies have been preliminary and scarce, we studied the effects of psychoanalytic therapy (PAT) versus cognitive-behavioural therapy (CBT) for chronic depression in adults with a history of childhood trauma. In this subgroup, we expected a greater symptom reduction in PAT compared with CBT.
methodIn a large trial of long-term psychotherapies for chronic depression (LAC-Study; Clinical Trial Register ISRCTN91956346), 210 adults received open-ended CBT or PAT in an out-patient setting and were examined yearly over 5 years on the Beck Depression Inventory - II (BDI-II). Based on a linear mixed model approach, we tested participant-reported childhood trauma based on the Childhood Trauma Questionnaire (CTQ) as a predictor and moderator of treatment outcome. CTQ subscales were examined exploratively.
resultsDepressive symptoms decreased over time (
conclusionsOur results indicate differential benefits from PAT compared with CBT among adults with chronic depression and a history of childhood trauma. The results have important implications for differential indication and policy.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.