Evidence map›Paper›PMID 39119946›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2024

Sensing of Liver-Derived Nicotinamide by Intestinal Group 2 Innate Lymphoid Cells Links Liver Cirrhosis and Ulcerative Colitis Susceptibility.

Jing Shen, Zhen Li, Xiaoyu Liu, Mengqi Zheng, Peng Zhang, Yatai Chen, Qiuheng Tian, Wenyu Tian, Guanjun Kou, Yanyan Cui and 13 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Dysregulated immunometabolism in gut inflammation.Acta biochimica et biophysica Sinica · 2026
    Review
  3. Article
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors.

Jing ShenDepartment of Gastroenterology, Qilu Hospital of Shandong University, Jinan, 250012, China.
Zhen LiDepartment of Gastroenterology, Qilu Hospital of Shandong University, Jinan, 250012, China.
Xiaoyu LiuAdvanced Medical Research Institute, Shandong University, Jinan, 250012, China.
Mengqi ZhengDepartment of Gastroenterology, Qilu Hospital of Shandong University, Jinan, 250012, China.
Peng ZhangDepartment of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Shandong University, Jinan, 250012, China.
Yatai ChenAdvanced Medical Research Institute, Shandong University, Jinan, 250012, China.
Qiuheng TianAdvanced Medical Research Institute, Shandong University, Jinan, 250012, China.
Wenyu TianAdvanced Medical Research Institute, Shandong University, Jinan, 250012, China.
Guanjun KouDepartment of Gastroenterology, Qilu Hospital of Shandong University, Jinan, 250012, China.
Yanyan CuiAdvanced Medical Research Institute, Shandong University, Jinan, 250012, China.
Bowen XuDepartment of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Shandong University, Jinan, 250012, China.
Yunjiao ZhaiAdvanced Medical Research Institute, Shandong University, Jinan, 250012, China.
Weijia LiDepartment of Gastroenterology, Qilu Hospital of Shandong University, Jinan, 250012, China.
Xiaohuan GuoInstitute for Immunology, School of Medicine, Tsinghua University, Beijing, 100084, China.
Ju QiuCAS Key Laboratory of Tissue Microenvironment and Tumor, Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, 200031, China.
Chunyang LiKey Laboratory for Experimental Teratology of Ministry of Education and Department of Histology and Embryology, School of Basic Medical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, 250012, China.
Ran HeDepartment of Immunology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 43003, China.
Lixiang LiDepartment of Gastroenterology, Qilu Hospital of Shandong University, Jinan, 250012, China.
Chunhong MaKey Laboratory for Experimental Teratology of Ministry of Education and Department of Histology and Embryology, School of Basic Medical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, 250012, China.
Yanqing LiDepartment of Gastroenterology, Qilu Hospital of Shandong University, Jinan, 250012, China.
Xiuli ZuoDepartment of Gastroenterology, Qilu Hospital of Shandong University, Jinan, 250012, China.
Detian YuanDepartment of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Shandong University, Jinan, 250012, China.
Shiyang LiDepartment of Gastroenterology, Qilu Hospital of Shandong University, Jinan, 250012, China.ORCID 0000-0003-1487-4991

Funding

National Key R&D Program of China 2020YFA0804400National Natural Science Foundation of China 21510082195014National Natural Science Foundation of China 32100590National Natural Science Foundation of China 81770538National Natural Science Foundation of China 81873550National Natural Science Foundation of China 82070552National Natural Science Foundation of China 82071854National Natural Science Foundation of China 82270621Natural Science Foundation of Shandong Province ZR2020QH038
6 · The paper itself

Abstract

The correlation between liver disease and the progression of ulcerative colitis (UC) has remained elusive. In this study, it demonstrates that liver injury is intricately linked to the heightened severity of UC in patients, and causes more profound intestinal damage during DSS-induced colitis in mice. Metabolomics analysis of plasma from liver cirrhosis patients shows liver injury compromising nicotinamide supply for NAD

Indexed as

Colitis, UlcerativeDisease Models, AnimalImmunity, InnateLiver CirrhosisLymphocytesMice, Inbred C57BLNiacinamideAnimalsDisease SusceptibilityFemaleHumansLiverMaleMiceNiacinamidegroup 2 innate lymphoid cellsliver‐gut axisliver injuryNAD+ metabolismnicotinamide phosphoribosyltransferaseulcerative colitis

Identifiers

PMID39119946
PMCPMC11481183

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.