Evidence map›Paper›PMID 39119830›Full record

Observational studyEuropean journal of ophthalmology2025

Bubble-graft coverage after Descemet Membrane Endothelial Keratoplasty depending on gaze angle.

Maximilian Friedrich, Hyeck-Soo Son, Rebecca Charlotte Buhl, Christine Maria Meyer, Timur Mert Yildirim, Ramin Khoramnia, Gerd Uwe Auffarth, Victor Aristide Augustin

Abstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in European journal of ophthalmology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Observational
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Maximilian FriedrichDavid J. Apple International Laboratory for Ocular Pathology and International Vision Correction Research Centre, Department of Ophthalmology, University of Heidelberg, Heidelberg, Germany.ORCID 0009-0000-8699-4613
Hyeck-Soo SonDavid J. Apple International Laboratory for Ocular Pathology and International Vision Correction Research Centre, Department of Ophthalmology, University of Heidelberg, Heidelberg, Germany.
Rebecca Charlotte BuhlDavid J. Apple International Laboratory for Ocular Pathology and International Vision Correction Research Centre, Department of Ophthalmology, University of Heidelberg, Heidelberg, Germany.
Christine Maria MeyerDavid J. Apple International Laboratory for Ocular Pathology and International Vision Correction Research Centre, Department of Ophthalmology, University of Heidelberg, Heidelberg, Germany.
Timur Mert YildirimDavid J. Apple International Laboratory for Ocular Pathology and International Vision Correction Research Centre, Department of Ophthalmology, University of Heidelberg, Heidelberg, Germany.
Ramin KhoramniaDavid J. Apple International Laboratory for Ocular Pathology and International Vision Correction Research Centre, Department of Ophthalmology, University of Heidelberg, Heidelberg, Germany.
Gerd Uwe AuffarthDavid J. Apple International Laboratory for Ocular Pathology and International Vision Correction Research Centre, Department of Ophthalmology, University of Heidelberg, Heidelberg, Germany.ORCID 0000-0002-6927-5251
Victor Aristide AugustinDavid J. Apple International Laboratory for Ocular Pathology and International Vision Correction Research Centre, Department of Ophthalmology, University of Heidelberg, Heidelberg, Germany.ORCID 0000-0002-6315-8484

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeIn Descemet Membrane Endothelial Keratoplasty (DMEK) a gas bubble is usually used to attach the graft to the host cornea. In this study, we observed the bubble size and bubble-graft coverage at different gaze angles following DMEK.

methodsThis observational prospective study analyzed 465 images of patients who underwent an uneventful DMEK. Intraoperatively, the anterior chamber was filled up to 90% of its volume with a 20% Sulfur Hexafluoride (SF

resultsThe highest bubble-graft coverage was achieved at a 0° gaze angle at all times of measurement. In the first 48 h after DMEK, the mean bubble-graft coverage was over 85% at a gaze angle between 0° and 45°. Starting 72 h after DMEK, the graft coverage declined at all gaze angles. The graft coverage at a 0° gaze angle was 88.61 ± 10.90% after 96 postoperative hours, while the graft coverage was below 85% at all other gaze angles.

conclusionOur clinical results provide novel insight into variation in bubble-graft coverage as a function of gaze angle and may be used to aid in patient counselling for appropriate body positioning following DMEK to prevent early graft detachment. Maintaining supine positioning seems to be most advantageous starting 48 h after DMEK.

Indexed as

Descemet Stripping Endothelial KeratoplastyEndothelium, CornealSulfur HexafluorideAgedAged, 80 and overAirFemaleGraft SurvivalHumansMaleMiddle AgedProspective StudiesVisual AcuitySulfur Hexafluoridecornea / external diseasecorneal dystrophies < cornea / external diseasecorneal topography / imaging systems < refractive surgeryCorneal transplantation < cornea / external diseaseexamination techniques < cornea / external disease

Identifiers

PMID39119830
PMCPMC11852538

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.