Evidence map›Paper›PMID 39119825›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2024

General Post-Regulation Strategy of AIEgens' Photophysical Properties for Intravital Two-Photon Fluorescence Imaging.

Liyun Lin, Jiaxin Liu, Zhengyuan Pan, Wen Pang, Xinyan Jiang, Man Lei, Jucai Gao, Yujie Xiao, Bo Li, Fang Hu and 4 more

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Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Liyun LinSchool of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, 200030, China.
Jiaxin LiuDepartment of Chemistry, Institute of Molecular Aggregation Science, Tianjin University, Tianjin, 300072, China.
Zhengyuan PanSchool of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, 200030, China.
Wen PangSchool of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, 200030, China.
Xinyan JiangSchool of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, 200030, China.
Man LeiSchool of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, 200030, China.
Jucai GaoBiomaterials Research Center, School of Biomedical Engineering, Southern Medical University, Guangzhou, 510515, China.
Yujie XiaoDepartment of Neurology, Huashan Hospital, MOE Frontiers Center for Brain Science, State Key Laboratory of Medical Neurobiology, Institutes for Translational Brain Research, Fudan University, Shanghai, 200437, China.
Bo LiDepartment of Neurology, Huashan Hospital, MOE Frontiers Center for Brain Science, State Key Laboratory of Medical Neurobiology, Institutes for Translational Brain Research, Fudan University, Shanghai, 200437, China.
Fang HuBiomaterials Research Center, School of Biomedical Engineering, Southern Medical University, Guangzhou, 510515, China.
Zhouzhou BaoShanghai Key Laboratory of Gynecologic Oncology, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200127, China.
Xunbin WeiLaboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Peking University Cancer Hospital & Institute, Beijing, 100142, China.
Wenbo WuDepartment of Chemistry, Institute of Molecular Aggregation Science, Tianjin University, Tianjin, 300072, China.
Bobo GuSchool of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, 200030, China.ORCID 0000-0001-6092-8001

Funding

National Key Research and Development Program of China 2021YFF0502900National Natural Science Foundation of China 22075199National Natural Science Foundation of China 52103228National Natural Science Foundation of China 62027824National Natural Science Foundation of China 62375169National Natural Science Foundation of China 82102123Natural Science Foundation of Shanghai 21ZR1438600Shanghai Jiao Tong University YG2022ZD005Shanghai Jiao Tong University YG2024QNA06Shanghai Rising-Star Program 23QC1400100
6 · The paper itself

Abstract

Fluorogens with aggregation-induced emission (AIEgens) are promising agents for two-photon fluorescence (TPF) imaging. However, AIEgens' photophysical properties are fixed and unoptimizable once synthesized. Therefore, it is urgent and meaningful to explore an efficient post-regulation strategy to optimize AIEgens' photophysical properties. Herein, a general and efficient post-regulation strategy is reported. By simply tuning the ratio of inert AIEgens within binary nanoparticles (BNPs), the fluorescence quantum yield and two-photon absorption cross-section of functional AIEgens are enhanced by 8.7 and 5.4 times respectively, which are not achievable by conventional strategies, and the notorious phototoxicity is almost eliminated. The experimental results, theoretical simulation, and mechanism analysis demonstrated its feasibility and generality. The BNPs enabled deep cerebrovascular network imaging with ≈1.10 mm depth and metastatic cancer cell detection with single-cell resolution. Furthermore, the TPF imaging quality is improved by the self-supervised denoising algorithm. The proposed binary molecular post-regulation strategy opened a new avenue to efficiently boost the AIEgens' photophysical properties and consequently TPF imaging quality.

Indexed as

Fluorescent DyesAnimalsHumansMiceMicroscopy, Fluorescence, MultiphotonNanoparticlesOptical ImagingPhotonsFluorescent Dyesaggregation‐induced emissiongeneral post‐regulationtwo‐photon fluorescence imaging

Identifiers

PMID39119825
PMCPMC11481373

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