Evidence map›Paper›PMID 39119517›Full record

ArticleFrontiers in chemistry2024

Design, synthesis, and bioevaluation of diarylpyrimidine derivatives as novel microtubule destabilizers.

Yutao Xiu, Yujing Zhang, Shanbo Yang, Lingyu Shi, Dongming Xing, Chao Wang

Abstract read
In one paragraph

Article in Frontiers in chemistry, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Yutao XiuCancer Institute, The Affiliated Hospital of Qingdao University, Qingdao University, Qingdao, Shandong, China.
Yujing ZhangThe Affiliated Cardiovascular Hospital of Qingdao University, Qingdao University, Qingdao, Shandong, China.
Shanbo YangCancer Institute, The Affiliated Hospital of Qingdao University, Qingdao University, Qingdao, Shandong, China.
Lingyu ShiCancer Institute, The Affiliated Hospital of Qingdao University, Qingdao University, Qingdao, Shandong, China.
Dongming XingCancer Institute, The Affiliated Hospital of Qingdao University, Qingdao University, Qingdao, Shandong, China.
Chao WangCancer Institute, The Affiliated Hospital of Qingdao University, Qingdao University, Qingdao, Shandong, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In this work, a series of new diarylpyrimidine derivatives as microtubule destabilizers were designed, synthesized, and evaluated for anticancer activities. Based on restriction configuration strategy, we introduced the pyrimidine moiety containing the hydrogen-bond acceptors as

Indexed as

antiproliferative activitycombretastatin A-4microtubule destabilizermolecular dockingpyrimidine

Identifiers

PMID39119517
PMCPMC11306069

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.