Evidence map›Paper›PMID 39119477›Full record

ArticleOpen forum infectious diseases2024

Molecular Epidemiology of Isoniazid-resistant

Kathleen F Walsh, Myung Hee Lee, Chrispin Chaguza, Widman Pamphile, Gertrude Royal, Vincent Escuyer, Jean W Pape, Daniel Fitzgerald, Ted Cohen, Oksana Ocheretina

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Open forum infectious diseases, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Kathleen F WalshGeneral Internal Medicine, Weill Cornell Medicine, New York, New York, USA.ORCID https://orcid.org/0000-0002-9001-3918
Myung Hee LeeCenter for Global Health, Weill Cornell Medicine, New York, New York, USA.
Chrispin ChaguzaDepartment of Epidemiology of Microbial Diseases, Yale School of Public Health, Yale University, New Haven, Connecticut, USA.
Widman PamphileGroupe Haitian d'Etude du Sarcoma da Kaposi at des Infections Opportunistas (GHESKIO), Port-au-Prince, Haiti.
Gertrude RoyalGroupe Haitian d'Etude du Sarcoma da Kaposi at des Infections Opportunistas (GHESKIO), Port-au-Prince, Haiti.
Vincent EscuyerWadsworth Center, New York State Department of Health, Albany, New York, USA.
Jean W PapeCenter for Global Health, Weill Cornell Medicine, New York, New York, USA.
Daniel FitzgeraldCenter for Global Health, Weill Cornell Medicine, New York, New York, USA.
Ted CohenDepartment of Epidemiology of Microbial Diseases, Yale School of Public Health, Yale University, New Haven, Connecticut, USA.
Oksana OcheretinaCenter for Global Health, Weill Cornell Medicine, New York, New York, USA.

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
Sentinel populations and transmission hotspots of isoniazid-resistant tuberculosisK23AI175686 · NIAID · WEILL MEDICAL COLL OF CORNELL UNIV · PI Kathleen F Walsh · 2023 to 2026
$782k
NCATS NIH HHS UL1 TR001863NIAID NIH HHS K23 AI175686
6 · The paper itself

Abstract

Background: Isoniazid-resistant, rifampin-susceptible tuberculosis (Hr-TB) is associated with poor treatment outcomes and higher rates of acquisition of further drug resistance during treatment. Due to a lack of widespread diagnostics, Hr-TB is frequently undetected and its epidemiology is incompletely understood. Methods: We studied the molecular epidemiology of Hr-TB among all patients diagnosed with culture-positive pulmonary tuberculosis between January 1 and June 30, 2017, at an urban referral tuberculosis clinic in Port-au-Prince, Haiti. Demographic and clinical data were extracted from the electronic medical record. Archived diagnostic Results and Conclusions: Among 845 patients with culture-positive pulmonary tuberculosis in Haiti, 65 (7.7%) had Hr-TB based on the Genotype MTBDR

Indexed as

adolescentepidemiologyisoniazidresistancetuberculosis

Identifiers

PMID39119477
PMCPMC11306977

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.