Evidence map›Paper›PMID 39119311›Full record

ReviewIndian journal of dermatology

Androgenetic Alopecia in Men: An Update On Genetics.

Ilakkia Priya Sadasivam, Ravikumar Sambandam, Damayandhi Kaliyaperumal, Jude Ernest Dileep

Abstract readReview
In one paragraph

Review in Indian journal of dermatology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Review
  4. Review
  5. Article
  6. Review
  7. Review
  8. Observational
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Ilakkia Priya SadasivamFrom the Department of Dermatology, Venereology and Leprosy, Aarupadai Veedu Medical College and Hospital, Vinayaka Mission Research Foundation (Deemed to be University), Puducherry, India.
Ravikumar SambandamDepartment of Medical Biotechnology, Aarupadai Veedu Medical College and Hospital, Vinayaka Mission Research Foundation (Deemed to be University), Puducherry, India.
Damayandhi KaliyaperumalFrom the Department of Dermatology, Venereology and Leprosy, Aarupadai Veedu Medical College and Hospital, Vinayaka Mission Research Foundation (Deemed to be University), Puducherry, India.
Jude Ernest DileepFrom the Department of Dermatology, Venereology and Leprosy, Aarupadai Veedu Medical College and Hospital, Vinayaka Mission Research Foundation (Deemed to be University), Puducherry, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Androgenetic alopecia (AGA) is defined as the alopecia induced by androgens in genetically predisposed individuals. AGA results in progressive miniaturization of the hair follicles leading to vellus transformation of terminal hair. The high prevalence and wide range of expressed phenotypes in AGA is a result of a polygenic inheritance mode. The androgen receptor (AR) gene located on the X chromosome at Xq11-12 is the first gene to show genetic association with AGA. Newer genetic associations with AGA are under study. In early-onset AGA, obesity, diabetes, hypertension, dyslipidaemia, insulin resistance, benign prostatic hyperplasia (BPH), prostate cancers and coronary artery disease (CAD) are associated with AGA. Screening of early-onset AGA patients and intervention for metabolic syndrome and insulin resistance can prevent the development of cardiovascular disease (CVD) at an early stage. As effective treatments continue to be topical minoxidil, systemic finasteride and hair transplantations, newer modalities are under investigation. Understanding the genetic factors involved in AGA and continued research into newer therapies, such as cell-based therapies, will lead to effective treatment and improve the quality of life in patients with AGA.

Indexed as

androgenetic alopeciaAndrogenic alopeciaandrogen receptor genesingle nucleotide polymorphism

Identifiers

PMID39119311
PMCPMC11305502

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.