Evidence map›Paper›PMID 39119280›Full record

ArticleRSC advances2024

2-Chloro-3-cyano-4-nitrobenzyl pyridinium bromide as a potent anti-lung cancer molecule prepared using a single-step solvent-free method.

Sadaiyan Govindaraj, Kilivelu Ganesan, Perumal Elumalai, Rajanathadurai Jeevitha, Annadurai Subramani, Mohammed Amanullah, Awad Saeed Al-Samghan

Abstract read
In one paragraph

Article in RSC advances, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Sadaiyan GovindarajPG& Research Department of Chemistry, Presidency College Chennai 600005 India kiliveluganesan@yahoo.co.in.
Kilivelu GanesanPG& Research Department of Chemistry, Presidency College Chennai 600005 India kiliveluganesan@yahoo.co.in.ORCID https://orcid.org/0000-0003-2127-4388
Perumal ElumalaiCancer Genomics lab, Center for Global Health Research, Saveetha Medical College and Hospitals, Saveetha Institute of Medical and Technical Sciences Chennai 602105 India.
Rajanathadurai JeevithaCancer Genomics lab, Center for Global Health Research, Saveetha Medical College and Hospitals, Saveetha Institute of Medical and Technical Sciences Chennai 602105 India.
Annadurai SubramaniDepartment of Chemistry, Dwaraka Doss Goverdhan Doss Vaishnav College Chennai 600106 India.
Mohammed AmanullahDepartment of Clinical Biochemistry, College of Medicine, King Khalid University Abha 61413 Kingdom of Saudi Arabia.
Awad Saeed Al-SamghanDepartment of Family Medicine and Community Medicine, College of Medicine, King Khalid University Abha Kingdom of Saudi Arabia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Mono-/dimeric-substituted pyridinium and pyrazolium bromides were prepared under conventional and solvent-free silica-supported domestic microwave conditions. The atom economy, environmental product mass intensity and product mass intensity for solvent-free reactions showed significant importance for the synthesis of target molecules. 4-Nitrobenzyl-substituted pyridinium bromide showed potent anticancer properties compared with mono-/dimeric-substituted pyridinium and pyrazolium bromides against a lung cancer cell line (A-549). Molecular simulation studies were carried out for mono-/dimeric-substituted pyridinium and pyrazolium bromide against protein human CDK1/cyclinB1/CKS2 using the AutoDock program.

Identifiers

PMID39119280
PMCPMC11309018

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.