Reversible cerebral vasoconstriction syndrome due to teprotumumab: two case reports.

Mohamed Elfil, Pashayar P Lookian, Kanchan Kumari, Mohammad Aladawi, Mark Jedras, Steven M Phillips, Mithun G Sattur

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Article in Oxford medical case reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

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2citing papers in PubMed

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2 citing papers in PubMed.

4 · The record

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5 · Who and what money

Authors and funding

7 authors.

Mohamed ElfilDepartment of Neurological Sciences, University of Nebraska Medical Center, 988440 Nebraska Medical Center, Omaha, NE 68198-8440, United States.ORCID https://orcid.org/0000-0002-1125-2946

Pashayar P LookianDepartment of Neurosurgery, University of Nebraska Medical Center, 4242 Farnam St., Omaha, NE 68131, United States.

Kanchan KumariDepartment of Neurological Sciences, University of Nebraska Medical Center, 988440 Nebraska Medical Center, Omaha, NE 68198-8440, United States.

Mohammad AladawiDepartment of Neurological Sciences, University of Nebraska Medical Center, 988440 Nebraska Medical Center, Omaha, NE 68198-8440, United States.

Mark JedrasDepartment of Neurological Sciences, University of Nebraska Medical Center, 988440 Nebraska Medical Center, Omaha, NE 68198-8440, United States.

Steven M PhillipsDepartment of Neurological Sciences, University of Nebraska Medical Center, 988440 Nebraska Medical Center, Omaha, NE 68198-8440, United States.

Mithun G SatturDepartment of Neurosurgery, University of Nebraska Medical Center, 4242 Farnam St., Omaha, NE 68131, United States.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundReversible Cerebral Vasoconstriction Syndrome (RCVS) involves cerebral vasculature constriction and dilation. While the exact pathophysiology of RCVS is still not fully understood, there are multiple etiological factors suggested to be implicated in triggering RCVS. We report two RCVS cases potentially linked to teprotumumab. Case 1: A 59-year-old female with Graves' eye disease (GED) developed leg weakness and headache after initiating teprotumumab, and neuroimaging studies revealed multifocal cerebral vasospasm (CVS). Verapamil mitigated vasospasm and the patient overall improved. Case 2: A 71-year-old female with GED developed thunderclap headache two months after starting teprotumumab, with subarachnoid hemorrhage (SAH) and CVS revealed on neuroimaging studies. The patient improved on verapamil and was discharged without deficits.

conclusionsThe temporal correlation between teprotumumab initiation and RCVS's symptom onset raises concern for the potential involvement of teprotumumab in triggering RCVS via disrupting cerebrovascular modulation. Further research is needed to investigate this proposed association.

Indexed as

graves’ eye diseaseinsulin-like growth factor-1monoclonal antibodyreversible cerebral vasoconstriction syndromesubarachnoid hemorrhageteprotumumabthyroid eye disease

Identifiers

PMID39119013

DOI10.1093/omcr/omae085

PMCPMC11304978

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