ArticleAlzheimer's & dementia (Amsterdam, Netherlands)
Association of optic disc pallor and RNFL thickness with cerebral small vessel disease in the PREVENT-Dementia study.
Article in Alzheimer's & dementia (Amsterdam, Netherlands). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Retinal hemodynamic and caliber biomarkers for the assessment of cerebral small vessel disease burden: insights from fundus fluorescein angiography.BMC neurology · 2026Article
- Optic Disc Pallor in Parkinson's Disease: A UK Biobank Study.Movement disorders : official journal of the Movement Disorder Society · 2025Article
- Association of optic disc pallor and RNFL thickness with cerebral small vessel disease in the PREVENT-Dementia study.Alzheimer's & dementia (Amsterdam, Netherlands)Article
- Association between choroidal microvasculature in the eye and Alzheimer's disease risk in cognitively healthy mid-life adults: A pilot study.Alzheimer's & dementia (Amsterdam, Netherlands)Article
- Sectoral Changes in Neuroretinal Rim Pallor Across Refractive Error.Ophthalmology scienceArticle
- Sensory changes in preclinical, prodromal, and clinical Alzheimer's disease and related dementias.Alzheimer's & dementia (Amsterdam, Netherlands)Article
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Authors and funding
10 authors.
Funding
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Abstract
introductionWe tested associations between two retinal measures (optic disc pallor, peripapillary retinal nerve fiber layer [pRNFL] thickness) and four magnetic resonance imaging markers of cerebral small vessel disease (SVD; lacunes, microbleeds, white matter hyperintensities, and enlarged perivascular spaces [ePVSs]).
methodsWe used PallorMetrics to quantify optic disc pallor from fundus photographs, and pRNFL thickness from optical coherence tomography scans. Linear and logistic regression assessed relationships between retinal measures and SVD markers. Participants (
resultsGlobal optic disc pallor was linked to ePVSs in the basal ganglia in both left ( DISCUSSION: Optic disc pallor correlated with ePVSs in the basal ganglia, suggesting retinal examination may be a useful method to study brain health changes related to SVD. Highlights: Optic disc pallor is linked to enlarged perivascular spaces in basal ganglia.There is no association between peripapillary retinal nerve fiber layer thickness and cerebral small vessel disease markers.Optic disc examination could provide insights into brain health.The sample included 108 midlife adults from the PREVENT Dementia study.
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