Evidence map›Paper›PMID 39118608›Full record

ArticleChemical science2024

A photo-SAR study of photoswitchable azobenzene tubulin-inhibiting antimitotics identifying a general method for near-quantitative photocontrol.

Martin Reynders, Małgorzata Garścia, Adrian Müller-Deku, Maximilian Wranik, Kristina Krauskopf, Luis de la Osa de la Rosa, Konstantin Schaffer, Anna Jötten, Alexander Rode, Valentin Stierle and 8 more

Abstract read
In one paragraph

Article in Chemical science, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Martin ReyndersFaculty of Chemistry and Pharmacy, Ludwig-Maximilians-University Munich Munich 81377 Germany oliver.thorn-seshold@cup.lmu.de.
Małgorzata GarściaFaculty of Chemistry and Pharmacy, Ludwig-Maximilians-University Munich Munich 81377 Germany oliver.thorn-seshold@cup.lmu.de.
Adrian Müller-DekuFaculty of Chemistry and Pharmacy, Ludwig-Maximilians-University Munich Munich 81377 Germany oliver.thorn-seshold@cup.lmu.de.
Maximilian WranikLaboratory of Biomolecular Research, Division of Biology and Chemistry, Paul Scherrer Institut Villigen 5232 Switzerland.
Kristina KrauskopfFaculty of Chemistry and Pharmacy, Ludwig-Maximilians-University Munich Munich 81377 Germany oliver.thorn-seshold@cup.lmu.de.
Luis de la Osa de la RosaFaculty of Chemistry and Pharmacy, Ludwig-Maximilians-University Munich Munich 81377 Germany oliver.thorn-seshold@cup.lmu.de.
Konstantin SchafferFaculty of Physics and Center for NanoScience (CeNS), Ludwig-Maximilians-University Munich Munich 80539 Germany.
Anna JöttenFaculty of Physics and Center for NanoScience (CeNS), Ludwig-Maximilians-University Munich Munich 80539 Germany.
Alexander RodeFaculty of Chemistry and Pharmacy, Ludwig-Maximilians-University Munich Munich 81377 Germany oliver.thorn-seshold@cup.lmu.de.
Valentin StierleFaculty of Physics and Center for NanoScience (CeNS), Ludwig-Maximilians-University Munich Munich 80539 Germany.
Yvonne KrausFaculty of Chemistry and Pharmacy, Ludwig-Maximilians-University Munich Munich 81377 Germany oliver.thorn-seshold@cup.lmu.de.
Benedikt BaumgartnerFaculty of Chemistry and Pharmacy, Ludwig-Maximilians-University Munich Munich 81377 Germany oliver.thorn-seshold@cup.lmu.de.
Ahmed AliFaculty of Chemistry and Pharmacy, Ludwig-Maximilians-University Munich Munich 81377 Germany oliver.thorn-seshold@cup.lmu.de.
Andrei BubeneckFaculty of Chemistry and Pharmacy, Ludwig-Maximilians-University Munich Munich 81377 Germany oliver.thorn-seshold@cup.lmu.de.
Trina SealFaculty of Chemistry and Pharmacy, Ludwig-Maximilians-University Munich Munich 81377 Germany oliver.thorn-seshold@cup.lmu.de.
Michel O SteinmetzLaboratory of Biomolecular Research, Division of Biology and Chemistry, Paul Scherrer Institut Villigen 5232 Switzerland.
Philipp PaulitschkeFaculty of Physics and Center for NanoScience (CeNS), Ludwig-Maximilians-University Munich Munich 80539 Germany.
Oliver Thorn-SesholdFaculty of Chemistry and Pharmacy, Ludwig-Maximilians-University Munich Munich 81377 Germany oliver.thorn-seshold@cup.lmu.de.ORCID https://orcid.org/0000-0003-3981-651X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Azobenzene analogues of the tubulin polymerisation inhibitor combretastatin A4 (PSTs) were previously developed to optically control microtubule dynamics in living systems, with subsecond response time and single-cell spatial precision, by reversible

Identifiers

PMID39118608
PMCPMC11304547

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.