ArticleACS infectious diseases2024
Pilot-Scale Screening of Clinically Approved Drugs to Identify Uridine Insertion/Deletion RNA Editing Inhibitors in
Mojtaba Rostamighadi, Arezou Kamelshahroudi, Vanessa Pitsitikas, Kenneth A Jacobson, Reza Salavati
Abstract read
In one paragraphArticle in ACS infectious diseases, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
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4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
5 authors.
Mojtaba RostamighadiInstitute of Parasitology, McGill University, Ste. Anne de Bellevue, Quebec H9X 3 V9, Canada.ORCID 0009-0008-6672-4892 Arezou KamelshahroudiInstitute of Parasitology, McGill University, Ste. Anne de Bellevue, Quebec H9X 3 V9, Canada.
Vanessa PitsitikasInstitute of Parasitology, McGill University, Ste. Anne de Bellevue, Quebec H9X 3 V9, Canada.
Kenneth A JacobsonMolecular Recognition Section, Laboratory of Bioorganic Chemistry, NIDDK, National Institutes of Health, 9000, Rockville Pike, Bethesda, Maryland 20892, United States.ORCID 0000-0001-8104-1493 Reza SalavatiInstitute of Parasitology, McGill University, Ste. Anne de Bellevue, Quebec H9X 3 V9, Canada.
Funding
Development Of Drugs Acting At Adenosine ReceptorsZIADK031117 · NIDDK · NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES · PI JACOBSON, KENNETH ALAN · 2009 to 2025
$10.4MFunctionalized Congeners Of Bioactive CompoundsZIADK031115 · NIDDK · NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES · PI JACOBSON, KENNETH ALAN · 2009 to 2025
$5.3MLarge-scale screen with a novel assay against RNA editing to identify anti-trypanosomal agentsR01AI143593 · NIAID · MCGILL UNIVERSITY · PI SALAVATI, REZA SALAVATI · 2019 to 2021
$1.3MDrugs that Act at Adenosine ReceptorsZ01DK031117 · NIDDK · NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES · PI JACOBSON, KENNETH ALAN · 1991 to 2008
$854kFUNCTIONALIZED CONGENERS OF BIOACTIVE COMPOUNDSZ01DK031115 · NIDDK · NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES · PI JACOBSON, KENNETH ALAN · 1991 to 2008
$577kIntramural NIH HHS Z01 DK031115Intramural NIH HHS Z01 DK031117Intramural NIH HHS Z99 DK999999Intramural NIH HHS ZIA DK031117NIAID NIH HHS R01 AI143593
6 · The paper itselfAbstract
RNA editing pathway is a validated target in kinetoplastid parasites (
Indexed as
RNA EditingTrypanosoma brucei bruceiUridineCatechinDrug Evaluation, PreclinicalDrug RepositioningHumansMolecular Docking SimulationProtozoan ProteinsTrypanocidal AgentsCatechinepigallocatechin gallateProtozoan ProteinsTrypanocidal AgentsUridineFRET-based assayskinetoplastidsmode of action studyNIH clinical collectionpilot scale screeningRNA editing
Identifiers
PMID39118542
PMCPMC11456206
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