Evidence map›Paper›PMID 39118380›Full record

ReviewFEMS microbiology reviews2024

Fungal primary and opportunistic pathogens: an ecological perspective.

Sybren de Hoog, Chao Tang, Xin Zhou, Bruna Jacomel, Bruno Lustosa, Yinggai Song, Hazal Kandemir, Sarah A Ahmed, Shaoqin Zhou, Ricardo Belmonte-Lopes and 4 more

Abstract readReview
In one paragraph

Review in FEMS microbiology reviews, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Is the Exophiala complex a silent threat in Brazil? A systematic review.International microbiology : the official journal of the Spanish Society for Microbiology · 2026
    Article
  2. Review
  3. Article
  4. Review
  5. Article
  6. Genomics and ecology ofIMA fungus · 2025
    Article
  7. Current medical mycology · 2025
    Article
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Sybren de HoogRadboudUMC-CWZ Centre of Expertise for Mycology, 6525GA Nijmegen, The Netherlands.ORCID 0000-0002-5344-257X
Chao TangRadboudUMC-CWZ Centre of Expertise for Mycology, 6525GA Nijmegen, The Netherlands.
Xin ZhouRadboudUMC-CWZ Centre of Expertise for Mycology, 6525GA Nijmegen, The Netherlands.
Bruna JacomelPostgraduate Program in Microbiology, Parasitology and Pathology, Biological Sciences, Department of Basic Pathology, Federal University of Paraná, 81531-980 Curitiba, Brazil.
Bruno LustosaRadboudUMC-CWZ Centre of Expertise for Mycology, 6525GA Nijmegen, The Netherlands.
Yinggai SongDepartment of Dermatology and Venerology, Peking University First Hospital,100034 Beijing, China.
Hazal KandemirWesterdijk Fungal Biodiversity Center, 3584CT Utrecht, The Netherlands.
Sarah A AhmedRadboudUMC-CWZ Centre of Expertise for Mycology, 6525GA Nijmegen, The Netherlands.
Shaoqin ZhouRadboudUMC-CWZ Centre of Expertise for Mycology, 6525GA Nijmegen, The Netherlands.
Ricardo Belmonte-LopesRadboudUMC-CWZ Centre of Expertise for Mycology, 6525GA Nijmegen, The Netherlands.
Yu QuanRadboudUMC-CWZ Centre of Expertise for Mycology, 6525GA Nijmegen, The Netherlands.
Peiying FengThird Affiliated Hospital of Sun Yat-sen University, 510630 Guangzhou, China.
Vania A VicentePostgraduate Program in Microbiology, Parasitology and Pathology, Biological Sciences, Department of Basic Pathology, Federal University of Paraná, 81531-980 Curitiba, Brazil.
Yingqian KangKey Laboratory of Environmental Pollution Monitoring and Disease Control, Ministry of Education of Guizhou & Key Laboratory of Medical Microbiology and Parasitology, School of Basic Medical Sciences, Guizhou Medical University, 561113 Guiyang, China.

Funding

International Science and Technology Cooperation Base of Guizhou Province [2020]4101
6 · The paper itself

Abstract

Fungal primary pathogenicity on vertebrates is here described as a deliberate strategy where the host plays a role in increasing the species' fitness. Opportunism is defined as the coincidental survival of an individual strain in host tissue using properties that are designed for life in an entirely different habitat. In that case, the host's infection control is largely based on innate immunity, and the etiologic agent is not transmitted after infection, and thus fungal evolution is not possible. Primary pathogens encompass two types, depending on their mode of transmission. Environmental pathogens have a double life cycle, and tend to become enzootic, adapted to a preferred host in a particular habitat. In contrast, pathogens that have a host-to-host transmission pattern are prone to shift to a neighboring, immunologically naive host, potentially leading to epidemics. Beyond these prototypical life cycles, some environmental fungi are able to make large leaps between dissimilar hosts/habitats, probably due to the similarity of key factors enabling survival in an entirely different niche, and thus allowing a change from opportunistic to primary pathogenicity. Mostly, such factors seem to be associated with extremotolerance.

Indexed as

FungiHost-Pathogen InteractionsMycosesAnimalsEcosystemHumansOpportunistic Infectionsadaptationclinical fungiinfection kineticslife cycleopportunismpathogenicity

Identifiers

PMID39118380
PMCPMC11409879

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.