ArticleVeterinary ophthalmology2025
Novel treatment of infectious keratitis in canine corneas using ultraviolet C (UV-C) light.
Article in Veterinary ophthalmology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
8 citing papers in PubMed.
- Efficacy of Therapeutic UVC Irradiation in Reducing Bacterial Load in Microbial Keratitis: A Retrospective Clinical Study in Veterinary Patients.Veterinary ophthalmology · 2026Article
- Assessment of Ocular Surface Pathogen Susceptibility to Ultraviolet-C (UVC) Light Treatment With a Novel Prototype Device-An In Vitro Study.Veterinary ophthalmology · 2026Article
- Antibiotics in Veterinary Ophthalmology: Resistance, Stewardship, and Emerging Antibiotic-Sparing Strategies.Veterinary ophthalmology · 2026Review
- Ultraviolet C (UV-C) Light Therapy Inhibits Pathogens Associated With Equine Keratomycosis at Different Corneal Depths-An Ex Vivo Study.Veterinary ophthalmology · 2026Article
- Antimicrobial Effect of Ultraviolet C (UV-C) Light Compared to Standard Povidone-Iodine Protocol for Preoperative Disinfection of the Periocular Area.Veterinary ophthalmology · 2026Article
- Antimicrobial Activity of Ultraviolet C Light as a Potential Novel Treatment for Moraxella bovis Infection-An In Vitro Study.Veterinary ophthalmology · 2026Article
- Novel treatment of infectious keratitis in canine corneas using ultraviolet C (UV-C) light.Veterinary ophthalmology · 2025Article
- Decoding the Gut Microbiome in Companion Animals: Impacts and Innovations.Microorganisms · 2024Review
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
objectiveTo investigate the therapeutic effect of 275 nm wavelength ultraviolet C (UV-C) light for treatment of bacterial keratitis in canine corneas using an affordable, broadly available modified handheld device.
methodsUV-C therapy (UVCT) was evaluated in two experiments: in vitro using triplicates of three bacterial genera (Staphylococcus, Streptococcus, Pseudomonas spp., and a mix of all species) where the UVCT was performed at a distance of 10, 15, and 20 mm with 1 or 2 doses (4 h apart) for 5, 15, or 30 s; ex vivo model where healthy canine corneal buttons were inoculated superficially and deep (330 μm) with the same bacterial isolates and treated at a 10 mm distance for 15 s with one dose of 22.5 mJ/cm
resultsIn vitro results showed all plates treated with UVCT had 100% bactericidal effect for all isolates with single dose of 15 s at 10 mm distance or two doses, 4 h apart at 15 mm and was ineffective with single dose at 15-20 mm. The ex vivo results confirmed a significant decrease in bacterial load for all isolates on samples inoculated superficially but were inconclusive for intrastromal ones.
conclusionsUVCT confirmed the therapeutic potential for all tested isolates, for both in vitro and ex vivo experiments using a single exposure of 15 s. While safety studies are underway, clinical trials are warranted.
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