Evidence map›Paper›PMID 39118264›Full record

Trial reportUnited European gastroenterology journal2024

Association between pancreatic adenocarcinoma risk and concentration of organochlorine pesticides in adipose tissue and urine: A targeted-screening analysis case-control study (PESTIPAC).

Mathias Brugel, Sidonie Callon, Claire Carlier, Koceila Lamine Amroun, Damien Botsen, Reza Kianmanesh, Marine Perrier, Tullio Piardi, Yohann Renard, Rami Rhaiem and 2 more

Registry-linked trialAbstract readClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in United European gastroenterology journal, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04429490 (Organochlorine Concentration in Adipose Tissue and Pancreatic Adenocarcinoma), which is not on this map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04429490 nacompletednot on this map

Organochlorine Concentration in Adipose Tissue and Pancreatic Adenocarcinoma : a Case Control Study.

TypeinterventionalSponsorCHU de ReimsRan2020 to 2023Enrolled56ConditionsCarcinoma, Pancreatic DuctalArmsAdipose tissue sampling during surgery and urine sampling
3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Trial
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Mathias BrugelGastroenterology and Digestive Oncology Department, Centre Hospitalier Côte Basque, Bayonne, France.ORCID 0000-0001-7574-9364
Sidonie CallonDigestive Oncology Department, CHU Reims, University of Reims Champagne-Ardenne (URCA), Reims, France.
Claire CarlierDigestive Oncology Department, CHU Reims, University of Reims Champagne-Ardenne (URCA), Reims, France.
Koceila Lamine AmrounGeneral, Digestive and Endocrine Surgery Department, CHU Reims, University of Reims Champagne-Ardenne (URCA), Reims, France.
Damien BotsenDigestive Oncology Department, CHU Reims, University of Reims Champagne-Ardenne (URCA), Reims, France.
Reza KianmaneshGeneral, Digestive and Endocrine Surgery Department, CHU Reims, University of Reims Champagne-Ardenne (URCA), Reims, France.
Marine PerrierGastroenterology and Digestive Oncology Department, Centre Hospitalier Côte Basque, Bayonne, France.
Tullio PiardiGeneral, Digestive and Endocrine Surgery Department, CHU Reims, University of Reims Champagne-Ardenne (URCA), Reims, France.
Yohann RenardGeneral, Digestive and Endocrine Surgery Department, CHU Reims, University of Reims Champagne-Ardenne (URCA), Reims, France.
Rami RhaiemGeneral, Digestive and Endocrine Surgery Department, CHU Reims, University of Reims Champagne-Ardenne (URCA), Reims, France.
Souleiman El BalkhiInserm, CHU Limoges, Pharmacology & Toxicology, U 1248, F-87000, Limoges, France.
Olivier BouchéDigestive Oncology Department, CHU Reims, University of Reims Champagne-Ardenne (URCA), Reims, France.

Funding

Action Foundation - Reims University Hospital
6 · The paper itself

Abstract

backgroundKnowledge about environmental pancreatic adenocarcinoma (PA) risk factors, including pesticide exposure, remains limited. Organochlorine (OC) accumulates in adipose tissue and can help reflect long-term exposure. PATIENTS AND

methodsAge and body mass index (BMI) of patients with PA were matched with those undergoing a surgery for a benign disease on age and BMI (1:1). Targeted analyses screened 345 pesticides and metabolites, including 29 OC, in adipose tissue and urine samples. The primary aim was to investigate the association between organochlorine concentrations in visceral fat or urine, and PA. Adjusted conditional logistic regressions were carried out accounting for multiple testing.

resultsTrans-nonachlor (odds ratio [OR] = 1.325, 95% confidence interval [CI] [1.108-1.586]), cis-nonachlor (OR = 15.433, 95% CI [2.733-87.136]), Mirex (OR = 2.853, 95% CI [1.213-6.713]) and 4,4 DDE (OR = 1.019, 95% CI [1.005-1.034]) in fat and a greater number of positive samples (OR = 1.758 95% CI [1.11-2.997]) were significantly associated with higher odds of PA. In contrast, as awaited, urine samples did not yield any statistically significant associations for all tested pesticides.

conclusionSome OCs were associated with higher odds of PA. The underlying mechanisms of pancreatic aggression need to be investigated to refine these findings.

trial registrationClinicaltrials.gov NCT04429490.

Indexed as

AdenocarcinomaHydrocarbons, ChlorinatedPancreatic NeoplasmsPesticidesAdipose TissueAdultAgedBody Mass IndexCase-Control StudiesEnvironmental ExposureFemaleHumansIntra-Abdominal FatLogistic ModelsMaleMiddle AgedHydrocarbons, ChlorinatedPesticidesadipose tissueenvironmental exposureorganochlorine pesticidespancreatic adenocarcinomapancreatic neoplasms

Identifiers

PMID39118264
PMCPMC11497671

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.