Evidence map›Paper›PMID 39118135›Full record

ArticleTrials2024

Short-term outcomes and inflammatory stress response following laparoscopy or robotic-assisted transabdominal preperitoneal inguinal hernia repair (TAPP): study protocol for a prospective, randomized trial (ROLAIS).

Alexandros Valsamidis Valorenzos, Kristian Als Nielsen, Karsten Kaiser, Per Helligsø, Mark Bremholm Ellebæk, Allan Dorfelt, Sofie Ronja Petersen, Andreas Kristian Pedersen, Michael Festersen Nielsen

Registry-linked trialAbstract readClinical Trial Protocol
In one paragraph

Article in Trials, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05839587 (Short-term Outcome and Inflammatory Stress Response Following Transabdominal Preperitoneal Inguinal Hernia Repair), which is not on this map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05839587 nacompletednot on this map

Short-term Outcome and Inflammatory Stress Response Following Transabdominal Preperitoneal Inguinal Hernia Repair (TAPP) - A Prospective, Randomized Trial Comparing Laparoscopy to the Robotic-assisted Approach

TypeinterventionalSponsorUniversity of Southern DenmarkRan2022 to 2025Enrolled150ConditionsHernia, Inguinal, LaparoscopyArmsRobotic TAPP, Laparoscopic TAPP
3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
  3. Review
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Alexandros Valsamidis ValorenzosDepartment of General Surgery, University Hospital of Southern Denmark, Aabenraa, Denmark. alex.n.valsamidis@gmail.com.ORCID http://orcid.org/0000-0002-0249-3406
Kristian Als NielsenDepartment of General Surgery, University Hospital of Southern Denmark, Aabenraa, Denmark.
Karsten KaiserDepartment of Gynecology and Obstetrics, University Hospital of Southern Denmark, Aabenraa, Denmark.
Per HelligsøDepartment of General Surgery, University Hospital of Southern Denmark, Aabenraa, Denmark.
Mark Bremholm EllebækResearch Unit of Surgery, Odense University Hospital, Odense, Denmark.
Allan DorfeltDepartment of General Surgery, Odense University Hospital, Odense, Denmark.
Sofie Ronja PetersenInstitute of Regional Health Research, University of Southern Denmark, Aabenraa, Denmark.
Andreas Kristian PedersenInstitute of Regional Health Research, University of Southern Denmark, Aabenraa, Denmark.
Michael Festersen NielsenDepartment of General Surgery, University Hospital of Southern Denmark, Aabenraa, Denmark.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundInguinal hernia repair is a frequently performed surgical procedure, with laparoscopic repair emerging as the preferred approach due to its lower complication rate and faster recovery compared to open repair. Mesh-based tension-free repair is the gold standard for both methods. In recent years, robotic hernia repair has been introduced as an alternative to laparoscopic repair, offering advantages such as decreased postoperative pain and improved ergonomics. This study aims to compare the short- and long-term outcomes, including the surgical stress response, postoperative complications, quality of life, and sexual function, between robotic-assisted transabdominal preperitoneal (rTAPP) and laparoscopic TAPP inguinal hernia repairs.

methodsThis randomized controlled trial will involve 150 patients from the Surgical Department of the University Hospital of Southern Denmark, randomized to undergo either rTAPP or laparoscopic TAPP. Surgical stress will be quantified by measuring C-reactive protein (CRP) and cytokine levels. Secondary outcomes include complication rates, quality of life, sexual function, and operative times. Data analysis will adhere to the intention-to-treat principle and will be conducted once all patient data are collected, with outcomes assessed at various postoperative intervals. DISCUSSION: This study holds significance in evaluating the potential advantages of robotic-assisted surgery in the context of inguinal hernia repairs. It is hypothesized that rTAPP will result in a lower surgical stress response and potentially lower the risk of postoperative complications compared to conventional laparoscopic TAPP. The implications of this research could influence future surgical practices and guidelines, with a focus on patient recovery and healthcare costs. The findings of this study will contribute to the ongoing discourse surrounding the utilization of robotic systems in surgery, potentially advocating for their broader implementation if the benefits are substantiated.

trial registrationClinicalTrials.gov NCT05839587. Retrospectively registered on 28 February 2023.

Indexed as

Hernia, InguinalHerniorrhaphyLaparoscopyQuality of LifeRandomized Controlled Trials as TopicRobotic Surgical ProceduresC-Reactive ProteinCytokinesDenmarkHumansInflammationMalePostoperative ComplicationsProspective StudiesTime FactorsTreatment OutcomeC-Reactive ProteinCytokinesAnatomicalHerniaInguinalPathological conditionsRobotic surgical procedures

Identifiers

PMID39118135
PMCPMC11308711

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.