Evidence map›Paper›PMID 39118130›Full record

ArticleWorld journal of surgical oncology2024

Peri- and postoperative morbidity and mortality in older patients with non-small cell lung cancer: a matched-pair study.

Seyer Safi, Maximilian Robert Gysan, Dorothea Weber, Rouven Behnisch, Thomas Muley, Michael Allgäuer, Hauke Winter, Hans Hoffmann, Martin Eichhorn

Abstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in World journal of surgical oncology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Seyer Safi *Division of Thoracic Surgery, University Hospital rechts der Isar, Technical University of Munich, Munich, Germany.
Maximilian Robert Gysan *Department of Thoracic Surgery, Heidelberg University Hospital, Thoraxklinik, Heidelberg, Germany.
Dorothea WeberInstitute of Medical Biometry and Informatics, University of Heidelberg, Heidelberg, Germany.
Rouven BehnischInstitute of Medical Biometry and Informatics, University of Heidelberg, Heidelberg, Germany.
Thomas MuleyTranslational Lung Research Center Heidelberg (TLRCH), Member of the German Center for Lung Research (DZL), Heidelberg, Germany.
Michael AllgäuerInstitute of Pathology, Heidelberg University Hospital, Heidelberg, Germany.
Hauke WinterDepartment of Thoracic Surgery, Heidelberg University Hospital, Thoraxklinik, Heidelberg, Germany.
Hans HoffmannDivision of Thoracic Surgery, University Hospital rechts der Isar, Technical University of Munich, Munich, Germany.
Martin EichhornDepartment of Thoracic Surgery, Heidelberg University Hospital, Thoraxklinik, Heidelberg, Germany. martin.eichhorn@med.uni-heidelberg.de.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundReports from case series suggest that operative outcomes are comparable amongst different age groups following surgery with curative intent for non-small cell lung cancer (NSCLC). The purpose of this study was to compare morbidity and mortality after NSCLC surgery in older patients (≥ 75 years) versus younger patients (< 75 years) and identify independent predictive risk factors.

methodsWe identified 2015 patients with postoperative stages IA to IIIA according to AJCC/UICC 7th edition who had undergone NSCLC surgery with curative intent at a single specialized lung cancer center from January 2010 to December 2015. A matched-pair analysis was performed on 227 older patients and corresponding 227 younger patients. Short-term surgical outcomes were postoperative morbidity, length of hospital stay, 30-day and 90-day mortality. Long-term operative outcomes were disease-free and overall survival.

results454 patients were included in the matched-pair analysis. 36% of younger patients developed postoperative complications versus 42% in older patients (p = 0.163). Age was not significantly associated with the occurrence of postoperative complications. Median length of hospital stay was 14 days in older patients and 13 days in younger patients (p = 0.185). 90-day mortality was 2.2% in younger patients compared to 4% in older patients (p = 0.424). In patients aged 75 and older impaired performance status (ECOG ≥ 1) was associated with decreased overall survival (HR = 2.15, CI 1.34-3.46), as were preoperative serum C-reactive protein / albumin ratio ≥ 0.3 (HR = 1.95, CI 1.23-3.11) and elevated preoperative serum creatinine levels ≥ 1.1 mg/dl (HR = 1.84, CI 1.15-2.95). In the younger cohort male sex (HR = 2.26, CI 1.17-4.36), postoperative stage III disease (HR 4.61, CI 2.23-9.54) and preoperative anemia (hemoglobin < 12 g/dl) (HR 2.09, CI 1.10-3.96) were associated with decreased overall survival.

conclusionsLung resection for NSCLC in older patients is associated with postoperative morbidity and mortality comparable to those of younger patients. In older patients, physical activity, comorbidities and nutritional status are related to survival and should influence the indication for surgery rather than age alone.

Indexed as

Age FactorsCarcinoma, Non-Small-Cell LungLung NeoplasmsPulmonary Surgical ProceduresAdultAgedAged, 80 and overC-Reactive ProteinCreatinineDatabases, FactualFemaleFunctional StatusHemoglobinsHospital MortalityHumansLength of StayC-Reactive ProteinCreatinineHemoglobinsSerum Albumin

Identifiers

PMID39118130
PMCPMC11311962

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