ArticleBMC public health2024
The association of circulating systemic inflammation with premature death and the protective role of the Mediterranean diet: a large prospective cohort study of UK biobank.
Article in BMC public health, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Association between systemic inflammation and long-term mortality in emergency department patients with severe hypertension.Clinics (Sao Paulo, Brazil) · 2026Article
- Association of dietary patterns with mortality and life expectancy by frailty status: Evidence from the UK Biobank.The journal of nutrition, health & aging · 2026Article
- Associations of dietary indices with risk of all-cause and cardiovascular mortality in hypertensive adults.Annals of medicine · 2025Article
- Causal Inference Framework Reveals Mediterranean Diet Superiority and Inflammatory Mediation Pathways in Mortality Prevention: A Comparative Analysis of Nine Common Dietary Patterns.Foods (Basel, Switzerland) · 2025Article
- Higher Food Inflammation Index Is Linearly Associated With Higher Risk of MASLD: A Cross-Sectional Study Based on the NHANES (1999-2020).Food science & nutrition · 2025Article
- Association between systemic inflammation biomarkers and incident cardiovascular disease in 423,701 individuals: evidence from the UK biobank cohort.Cardiovascular diabetology · 2025Article
- Systemic immune-inflammation index and long-term mortality in patients with hypertension: a cohort study.Journal of hypertension · 2025Article
- Exploring the association between pro-inflammatory diets and chronic liver diseases: evidence from the UK Biobank.Frontiers in nutrition · 2025Article
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Authors and funding
10 authors.
Funding
Abstract
backgroundAlthough previous studies have identified specific circulating inflammatory markers associated with the risk of mortality, they have often overlooked the broader impact of a comprehensive inflammatory response on health outcomes. This study aims to assess the association between circulating systemic inflammation and age-related hospitalization and premature death, as well as explore the potential mediating effects of various dietary patterns on these associations.
methodsA total of 448,574 participants enrolled in the UK Biobank study were included. Circulating C-reactive protein(CRP), white blood cell count(WBC), platelet count(Plt), and neutrophil/lymphocyte ratio(NLR) were measured, which were used to establish a weighted systemic inflammatory index of inflammation index(INFLA-Score). Dietary intake information was documented through 24-hour dietary recalls, and dietary pattern scores including Dietary Approaches to Stop Hypertension(DASH), Mediterranean(MED), and Healthy Eating Index-2020(HEI-2020) were calculated. Cox proportional hazards regression models were performed to assess the associations between INFLA-Score and age-related disease hospitalization, cause-specific and all-cause premature death.
resultsDuring a median follow-up of 12.65 years, 23,784 premature deaths were documented. After adjusting for multiple covariates, higher levels of CRP, WBC, NLR, and INFLA-Score were significantly associated with increased risks of age-related disease hospitalization(HR
conclusionA higher INFLA-Score was correlated with an increased risk of age-related hospitalization and premature death. Nevertheless, adherence to a Mediterranean (MED) diet may mitigate these associations.
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