Evidence map›Paper›PMID 39118086›Full record

ArticleMicrobial cell factories2024

Characterization of GQA as a novel β-lactamase inhibitor of CTX-M-15 and KPC-2 enzymes.

Lamiaa A Al-Madboly, Mohamed A Abd El-Salam, Jairo K Bastos, Shaimaa Aboukhatwa, Rasha M El-Morsi

Abstract read
In one paragraph

Article in Microbial cell factories, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Lamiaa A Al-MadbolyDepartment of Microbiology and Immunology, Faculty of Pharmacy, Tanta University, Tanta, Egypt. lamia.youssif@pharm.tanta.edu.eg.
Mohamed A Abd El-SalamDepartment of Pharmacognosy, Faculty of Pharmacy, Delta University for Science and Technology, International Coastal Road, Gamasa, 11152, Egypt. mohamed.abdelsalam@deltauniv.edu.eg.
Jairo K BastosDepartment of Pharmaceutical Sciences, School of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo, São Paulo, SP, 14040-903, Brazil.
Shaimaa AboukhatwaDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, Tanta University, Tanta, Egypt.
Rasha M El-MorsiDepartment of Microbiology and Immunology, Faculty of Pharmacy, Delta University for Science and Technology, International Coastal Road, Gamasa, 11152, Egypt.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

β-lactam resistance is a significant global public health issue. Outbreaks of bacteria resistant to extended-spectrum β-lactams and carbapenems are serious health concerns that not only complicate medical care but also impact patient outcomes. The primary objective of this work was to express and purify two soluble recombinant representative serine β‑lactamases using Escherichia coli strain as an expression host and pET101/D as a cloning vector. Furthermore, a second objective was to evaluate the potential, innovative, and safe use of galloylquinic acid (GQA) from Copaifera lucens as a potential β-lactamase inhibitor.In the present study, bla

Indexed as

beta-Lactamase Inhibitorsbeta-LactamasesEscherichia coliMicrobial Sensitivity TestsAnti-Bacterial AgentsBacterial ProteinsCarbapenemsKlebsiella pneumoniaeAnti-Bacterial AgentsBacterial Proteinsbeta-lactamase CTX-M-15beta-Lactamase Inhibitorsbeta-lactamase KPC-2beta-LactamasesCarbapenemsCarbapenemaseEscherichia coliExtended-spectrum β-lactamasesGalloylquinic acidKlebsiella pneumoniaeβ-lactamase inhibitor

Identifiers

PMID39118086
PMCPMC11308155

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.