Trial reportBMC pediatrics2024
Cooling during transportation of newborns with hypoxic ischemic encephalopathy using phase change material mattresses in low-resource settings: a randomized controlled trial in Hanoi, Vietnam.
Trial report in BMC pediatrics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05361473 (Evaluation of a Mattress With Phase Change Material Can be Helpful to Start Hypothermia During Transport Before Admissions to Neonatal Ward), which is not on this map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Evaluation of a Mattress With Phase Change Material Can be Helpful to Start Hypothermia During Transport Before Admissions to Neonatal Ward
Who cites it
4 citing papers in PubMed.
- Early Prediction of Outcome Using Lactate Dehydrogenase and Amplitude-Integrated EEG in Transported Newborn Infants with Hypoxic-Ischaemic Encephalopathy.Acta paediatrica (Oslo, Norway : 1992) · 2026Trial
- [Expert consensus on the clinical management of therapeutic hypothermia for neonatal hypoxic-ischemic encephalopathy (2026)].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2026Article
- Therapeutic hypothermia success for hypoxic-ischaemic encephalopathy in Latin America: Eight-year experience in EpicLatino Neonatal Network.Acta paediatrica (Oslo, Norway : 1992) · 2025Observational
- Neonatal Emergency Transport Organisation and Activities in Italy-The Nationwide 2023 Survey by the Neonatal Transport Study Group of the Italian Society of Neonatology.Children (Basel, Switzerland) · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo determine the effectiveness of phase-change-material mattress (PCM) during transportation of newborns with hypoxic ischemic encephalopathy (HIE). STUDY
designRandomized controlled trial of newborns with HIE from June 2016 to December 2019. Patients were randomized to transport with PCM or without PCM (control) when transferred to a cooling center in northern Vietnam. Primary outcome measure was mortality rate, secondary outcomes including temperature control and adverse effects.
resultFifty-Two patients in PCM-group and 61 in control group. Median rectal temperature upon arrival was 34.5 °C (IQR 33.5-34.8) in PCM-group and 35.1 °C (IQR 34.5-35.9) in control group (p = 0.023). Median time from birth to reach target temperature was 5.0 ± 1.4 h and 5.5 ± 1.2 h in the respective groups (p = 0.065). 81% of those transported with PCM versus 62% of infants transported without (p = 0.049) had reached target temperature within the 6-h timeframe. There was no record of overcooling (< 32 °C) in any of the groups. The was no difference in mortality rate between the two groups (33% and 34% respectively (p > 0.05)).
conclusionPhase-change-material can be used as a safe and effective cooling method during transportation of newborns with HIE in low-resource settings.
trial registrationThe study was retro-prospectively registered in Clinical Trials (04/05/2022, NCT05361473).
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