Evidence map›Paper›PMID 39118035›Full record

ArticleBMC cancer2024

Comparative effectiveness of perioperative physical activity in older adults with lung cancer and their family caregivers: design of a multicenter pragmatic randomized trial.

Virginia Sun, Katherine A Guthrie, Kathryn B Arnold, Mara Antonoff, Loretta Erhunmwunsee, Andrea Borondy-Kitts, Judy Johnson, Lee Jones, Maria Ramirez, Betty C Tong and 11 more

Registry-linked trialAbstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC cancer, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06196008 (SR2204), which is not on this map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06196008 narecruitingnot on this map

SR2204: A Randomized Phase III Trial of a Perioperative Physical Activity Intervention in Older Adults With Lung Cancer and Their Family Caregivers

TypeinterventionalSponsorCity of Hope Medical CenterRan2023 to 2028Enrolled382ConditionsLung CarcinomaArmsEducational Intervention, Exercise Intervention, Medical Device Usage and Evaluation, Physical Performance Testing, Quality-of-Life Assessment
3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Effects of a rehabilitation program based on home intelligent management platform guided among patient after lung cancer surgery: a randomized controlled trail.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026
    Trial
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Virginia SunDepartment of Population Sciences, City of Hope, 1500 East Duarte Road, Duarte, CA, 91010, USA. vsun@coh.org.
Katherine A GuthrieSWOG Statistics and Data Management Center, Fred Hutchinson Cancer Center, Seattle, WA, USA.
Kathryn B ArnoldSWOG Statistics and Data Management Center, Fred Hutchinson Cancer Center, Seattle, WA, USA.
Mara AntonoffDepartment of Thoracic and Cardiovascular Surgery, Division of Surgery, MD Anderson Cancer Center, Houston, TX, USA.
Loretta ErhunmwunseeDivision of Thoracic Surgery, Department of Surgery, City of Hope, Duarte, CA, USA.
Andrea Borondy-KittsFamily Caregiver Research Advocate, Jupiter, FL, USA.
Judy JohnsonFamily Caregiver Research Advocate, St. Louis, MO, USA.
Lee JonesPatient Research Advocate, Arlington, VA, USA.
Maria RamirezPatient Research Advocate, Lancaster, CA, USA.
Betty C TongDivision of Cardiovascular and Thoracic Surgery, Department of Surgery, Duke University, Durham, NC, USA.
Jacob R MoremenDivision of Thoracic Surgery, University of Mississippi Medical Center, Jackson, MS, USA.
Chi-Fu Jeffrey YangDivision of Thoracic Surgery, Massachusetts General Hospital, Boston, MA, USA.
Thomas NgDivision of Thoracic Surgery, University of Tennessee Health Sciences Center, Memphis, TN, USA.
Samuel S KimDivision of Thoracic Surgery, Northwestern University, Chicago, IL, USA.
Lisa M BrownDivision of General Thoracic Surgery, UC Davis Health, Sacramento, CA, USA.
Justin D BlasbergDivision of Thoracic Surgery, Yale University, New Haven, CT, USA.
Natalie S LuiDepartment of Cardiothoracic Surgery, Stanford University School of Medicine, Stanford, CA, USA.
Peter J KneuertzDivision of Thoracic Surgery, The Ohio State University Wexner Medical Center, Columbus, OH, USA.
Eric M TolozaDepartment of Thoracic Oncology, Moffitt Cancer Center, Tampa, FL, USA.
Jae Y KimDivision of Thoracic Surgery, Department of Surgery, City of Hope, Duarte, CA, USA.
Dan J RazDivision of Thoracic Surgery, Department of Surgery, City of Hope, Duarte, CA, USA.

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
SWOG NCORP Research BaseUG1CA189974 · NCI · THE HOPE FOUNDATION · PI CHARLES D. BLANKE, DAWN HERSHMAN · 2014 to 2026
$80.6M
NCATS NIH HHS UL1 TR001863NCI NIH HHS UG1 CA189974Patient-Centered Outcomes Research Institute HA-2021C3-24773
6 · The paper itself

Abstract

backgroundWith a median age at diagnosis of 70, lung cancer remains a significant public health challenge for older Americans. Surgery is a key component in treating most patients with non-metastatic lung cancer. These patients experience postoperative pain, fatigue, loss of respiratory capacity, and decreased physical function. Data on quality of life (QOL) in older adults undergoing lung cancer surgery is limited, and few interventions are designed to target the needs of older adults and their family caregivers (FCGs). The primary aim of this comparative effectiveness trial is to determine whether telephone-based physical activity coaching before and after surgery will be more beneficial than physical activity self-monitoring alone for older adults and their FCGs.

methodsIn this multicenter comparative effectiveness trial, 382 older adults (≥ 65 years) with lung cancer and their FCGs will be recruited before surgery and randomized to either telephone-based physical activity coaching or physical activity self-monitoring alone. Participants allocated to the telephone-based coaching comparator will receive five telephone sessions with coaches (1 pre and 4 post surgery), an intervention resource manual, and a wristband pedometer. Participants in the self-monitoring only arm will receive American Society of Clinical Oncology (ASCO) physical activity information and wristband pedometers. All participants will be assessed at before surgery (baseline), at discharge, and at days 30, 60, and 180 post-discharge. The primary endpoint is the 6-minute walk test (6MWT) at 30 days post-discharge. Geriatric assessment, lower extremity function, self-reported physical function, self-efficacy, and QOL will also be assessed. DISCUSSION: The trial will determine whether this telephone-based physical activity coaching approach can enhance postoperative functional capacity and QOL outcomes for older adults with lung cancer and their FCGs. Trial results will provide critical findings to inform models of postoperative care for older adults with cancer and their FCGs.

trial registrationClinicalTrials.gov Identifier: NCT06196008.

Indexed as

CaregiversExerciseLung NeoplasmsQuality of LifeAgedComparative Effectiveness ResearchFemaleHumansMaleMulticenter Studies as TopicPerioperative CarePragmatic Clinical Trials as TopicRandomized Controlled Trials as TopicTelephoneFamily caregiversFunctional recoveryLung cancerOlder adultsSurgery

Identifiers

PMID39118035
PMCPMC11312238

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.