Evidence map›Paper›PMID 39118019›Full record

ArticleBMC infectious diseases2024

Prevalence and factors associated with hepatitis B susceptibility among men who sex with men on HIV pre-exposure prophylaxis in Northeastern Brazil: a cross-sectional study.

Hareton Teixeira Vechi, Cláudio Henrique Silva de Freitas, Fernanda de Lira Nunes Paulino, Marina Gabriela Medeiros de Moura, Júlia Gomes Fernandes Costa de Sant'anna, Mônica Baumgardt Bay, Kenio Costa de Lima

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Article in BMC infectious diseases, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Hareton Teixeira VechiInstitute of Tropical Medicine, Federal University of Rio Grande do Norte, 300 Cônego Monte Street, Quintas, Natal, RN, 59037-170, Brazil. haretonvechi@gmail.com.
Cláudio Henrique Silva de FreitasInstitute of Tropical Medicine, Federal University of Rio Grande do Norte, 300 Cônego Monte Street, Quintas, Natal, RN, 59037-170, Brazil.
Fernanda de Lira Nunes PaulinoInstitute of Tropical Medicine, Federal University of Rio Grande do Norte, 300 Cônego Monte Street, Quintas, Natal, RN, 59037-170, Brazil.
Marina Gabriela Medeiros de MouraInstitute of Tropical Medicine, Federal University of Rio Grande do Norte, 300 Cônego Monte Street, Quintas, Natal, RN, 59037-170, Brazil.
Júlia Gomes Fernandes Costa de Sant'annaInstitute of Tropical Medicine, Federal University of Rio Grande do Norte, 300 Cônego Monte Street, Quintas, Natal, RN, 59037-170, Brazil.
Mônica Baumgardt BayDepartment of Infectious Diseases, Federal University of Rio Grande do Norte, 300 Cônego Monte Street, Quintas, Natal, RN, 59037-170, Brazil.
Kenio Costa de LimaDepartment of Odontology, Federal University of Rio Grande do Norte, 1787 Senador Salgado Filho Avenue, Lagoa Nova, Natal, RN, 59056-000, Brazil.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThis study aimed to determine the prevalence and factors associated with susceptibility to hepatitis B virus (HBV) among cisgender men who have sex with men (MSM) on HIV pre-exposure prophylaxis (PrEP) in Northeastern Brazil.

methodsThis was a cross-sectional, analytical study conducted between September 2021 and June 2023. Participants underwent structured interviews to collect sociodemographic and clinical information, including hepatitis B vaccination history, HIV PrEP use and sexual health history. Blood samples were collected for hepatitis B serologic testing: HBV surface antigen (HBsAg), HBV surface antibody (anti-HBs), total and IgM HBV core antibody (anti-HBc). HBV susceptibility was defined as nonreactive results for all these serological markers.

resultsA total of 287 participants were enrolled into the study. The median age of the individuals was 31 years (interquartile range: 27; 36). HBV susceptibility was found in 58 out 286 individuals (20.3%; 95% CI: 15.9-25.2). Seventy-six percent of the participants reported completing the three-dose hepatitis B vaccine schedule. Susceptibility was significantly associated with a monthly income ≤ 5 minimum wages (PR: 2.02; 95% CI: 1.01-4.05), lack of complete hepatitis B vaccination schedule (PR: 4.52; 95% CI: 2.89-7.06), initiation of HIV PrEP (PR: 2.18; 95% CI: 1.21-3.94), duration of six months of HIV PrEP (PR: 2.16; 95% CI: 1.19-3.91), absence of tattoos (PR: 1.55; 95% CI: 1.00-2.40) and no history of sexually transmitted infections (PR: 1.65; 95% CI: 1.07-2.54).

conclusionOur findings highlight the significant burden of HBV susceptibility among MSM on HIV PrEP in Northeastern Brazil. Socioeconomic factors, vaccination status, PrEP use and sexual health behaviors play critical roles in determining susceptibility to HBV. Integrating hepatitis B screening and vaccination into PrEP services is critical for identifying and addressing HBV susceptibility among MSM. Interventions aimed at increasing vaccination coverage and promoting safer sexual practices are essential for mitigating the burden of HBV infection in this population.

Indexed as

Hepatitis BHIV InfectionsHomosexuality, MalePre-Exposure ProphylaxisAdultBrazilCross-Sectional StudiesDisease SusceptibilityHepatitis B AntibodiesHepatitis B Surface AntigensHepatitis B VaccinesHepatitis B virusHumansMalePrevalenceRisk FactorsHepatitis B AntibodiesHepatitis B Surface AntigensHepatitis B VaccinesHepatitis BMen who have sex with menPre-exposure prophylaxisVaccines

Identifiers

PMID39118019
PMCPMC11308250

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.